3-(3,5-dimethoxyphenyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrrole-2,5-dione | 1407493-54-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(3,5-dimethoxyphenyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrrole-2,5-dione
• CAS: 1407493-54-2
• 化学式: C₁₉H₁₅N₃O₄
• 分子量: 349.346
• InChiKey: XWKUQHNIYPALRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  93.3
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(3,5-dimethoxyphenyl)acetyl chloride 在 potassium tert-butylate 、 氨 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 16.0h， 生成 3-(3,5-dimethoxyphenyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrrole-2,5-dione
  参考文献：
  名称：

  Novel 3-Azaindolyl-4-arylmaleimides Exhibiting Potent Antiangiogenic Efficacy, Protein Kinase Inhibition, and Antiproliferative Activity

  摘要：

  Tumor growth and metastasis are highly associated with the overexpression of protein kinases (PKs) regulating cell growth, apoptosis resistance, and prolonged cell survival. This study describes novel azaindolyl-maleimides with significant inhibition of PKs, such as VEGFR, FLT-3, and GSK-3 beta which are related to carcinogenesis. Furthermore, these compounds exhibit high kinase selectivity and potent inhibition of angiogenesis and cell proliferation, offering versatile options in cancer treatment strategies.

  DOI：

  10.1021/jm301217c

文献信息

• Novel 3-Azaindolyl-4-arylmaleimides Exhibiting Potent Antiangiogenic Efficacy, Protein Kinase Inhibition, and Antiproliferative Activity
  作者：Christopher Ganser、Eva Lauermann、Annett Maderer、Torsten Stauder、Jan-Peter Kramb、Stanislav Plutizki、Thomas Kindler、Markus Moehler、Gerd Dannhardt

  DOI：10.1021/jm301217c

  日期：2012.11.26

  Tumor growth and metastasis are highly associated with the overexpression of protein kinases (PKs) regulating cell growth, apoptosis resistance, and prolonged cell survival. This study describes novel azaindolyl-maleimides with significant inhibition of PKs, such as VEGFR, FLT-3, and GSK-3 beta which are related to carcinogenesis. Furthermore, these compounds exhibit high kinase selectivity and potent inhibition of angiogenesis and cell proliferation, offering versatile options in cancer treatment strategies.