3-叠氮基-2-氟吡啶 | 864866-10-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 3-叠氮基-2-氟吡啶
• 英文名称: 3-azido-2-fluoropyridine
• CAS: 864866-10-4
• 化学式: C₅H₃FN₄
• mdl: MFCD17676631
• 分子量: 138.104
• InChiKey: VHJMGTKGDXFYOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  27.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-叠氮基-2-氟吡啶 在 四(三苯基膦)钯 作用下， 以 甲苯 为溶剂， 反应 3.0h， 生成 1-(2-fluoropyridine-3-yl)-4-(2,2-dimethyl-1-oxo-indene-5-yl)-5-methyl-1H-[1,2,3]triazole
  参考文献：
  名称：

  EP1726585

  摘要：

  公开号：
• 作为产物：
  描述：

  2-氟吡啶 在 lithium diisopropyl amide 、 4-dodecylbenzenesulfonyl azide 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.17h， 生成 3-叠氮基-2-氟吡啶
  参考文献：
  名称：

  Synthesis and evaluation of 6-[1-(2-[18F]fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain

  摘要：

  The purpose of this study was to synthesize 6-[1-(2-[F-18]fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline ([F-18]FPTQ, [F-18]7a) and to evaluate its potential as a positron emission tomography ligand for imaging metabotropic glutamate receptor type 1 (mGluR1) in the rat brain. Compound [F-18]7a was synthesized by [F-18] fluorination of 6-[1-(2-bromo-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl] quinoline (7b) with potassium [F-18] fluoride. At the end of synthesis, 1280-1830 MBq (n = 8) of [F-18]7a was obtained with >98% radiochemical purity and 118-237 GBq/mu mol specific activity using 3300-4000 MBq of [F-18]F . In vitro autoradiography showed that [F-18]7a had high specific binding with mGluR1 in the rat brain. Biodistribution study using a dissection method and small-animal PET showed that [F-18]7a had high uptake in the rat brain. The uptake of radioactivity in the cerebellum was reduced by unlabeled 7a and mGluR1-selective ligand JNJ-16259685 (2), indicating that [F-18]7a had in vivo specific binding with mGluR1. Because of a low amount of radiolabeled metabolite present in the brain, [F-18]7a may have a limiting potential for the in vivo imaging of mGluR1 by PET. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.11.048

文献信息

• EP1764362
  申请人：——

  公开号：——

  公开（公告）日：——
• Discovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist
  作者：Satoru Ito、Atsushi Satoh、Yasushi Nagatomi、Yukari Hirata、Gentaroh Suzuki、Toshifumi Kimura、Akio Satow、Shunsuke Maehara、Hirohiko Hikichi、Mikiko Hata、Hiroshi Kawamoto、Hisashi Ohta

  DOI：10.1016/j.bmc.2008.09.060

  日期：2008.11

  We describe here the discovery and the structure-activity relationship (SAR) of a series of 4-(1-Aryl-triazol-4- yl)-tetrahydropyridines as novel mGluR1 antagonists. Our extensive chemical modi. cation of lead compound 2 successfully led to fluoropyridine analogs 7j and 1 with improved in vivo antagonistic activities. Among the evaluated compounds, chemically stable urea analog 1 showed oral antagonistic activity at dose ranges of 10-30 mg/kg in an animal model. (C) 2008 Elsevier Ltd. All rights reserved.
• CN115677668
  申请人：——

  公开号：——

  公开（公告）日：——