3-(2-Sulfanylacetamido)-N-(sulfanylacetyl)-L-alanine | 82793-86-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(2-Sulfanylacetamido)-N-(sulfanylacetyl)-L-alanine
• 英文别名: (2S)-2,3-bis[(2-sulfanylacetyl)amino]propanoic acid
• CAS: 82793-86-0
• 化学式: C₇H₁₂N₂O₄S₂
• 分子量: 252.3
• InChiKey: HWBGXDRNFUYNMF-BYPYZUCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  97.5
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• [EN] STABILIZATION OF PEPTIDIC RADIOPHARMACEUTICALS USING URIC ACID OR DERIVATIVES THEREOF<br/>[FR] STABILISATION DE PRODUITS RADIOPHARMACEUTIQUES PEPTIDIQUES À L'AIDE DE L'ACIDE URIQUE OU DES DÉRIVÉS DE CELUI-CI
  申请人：PIRAMAL IMAGING SA

  公开号：WO2013093099A1

  公开（公告）日：2013-06-27

  The present invention relates to novel stabilizing agents (stabilizers) of radiopharmaceutical compositions used for diagnosis and therapy. In particular the invention relates to use of an uric acid derivative to increase the shelf-life of diagnostic and therapeutic peptidic radiopharmaceuticals by reducing the sides products originated from radiolysis.
• [EN] PEPTIDES BASED TARGETING OF THE PLATELET DERIVED GROWTH FACTOR RECEPTOR BETA (PDGFRbeta) AND CD276<br/>[FR] CIBLAGE À BASE DE PEPTIDES DU RÉCEPTEUR BÊTA DU FACTEUR DE CROISSANCE DÉRIVÉ DES PLAQUETTES (PDGFRBeta) ET DU LIGAND CD276
  申请人：UNIVERSITAETSKLINIKUM HEIDELBERG

  公开号：WO2013132094A1

  公开（公告）日：2013-09-12

  The present invention concerns novel peptides and pentamer binding to PDGFRβ and CD276 proteins that are up regulated in cancer. Novel peptides and pentamer are radiolabeled for imaging of cancer and/or for radiotherapy. Method for imaging and treatment as well as method for obtaining radiopharmaceutical agent and medicament is disclosed.