Gly-Ser-Arg | 85530-46-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Gly-Ser-Arg
• 英文别名: (2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
• CAS: 85530-46-7
• 化学式: C₁₁H₂₂N₆O₅
• 分子量: 318.33
• InChiKey: YOBGUCWZPXJHTN-BQBZGAKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.2
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  206
• 氢给体数：
  7
• 氢受体数：
  7

文献信息

• IRRIGATION SOLUTION AND METHOD FOR INHIBITION OF TUMOR CELL ADHESION, PAIN AND INFLAMMATION
  申请人：Omeros Corporation

  公开号：EP1567179A1

  公开（公告）日：2005-08-31
• EP1567179A4
  申请人：——

  公开号：EP1567179A4

  公开（公告）日：2007-06-27
• [EN] IRRIGATION SOLUTION AND METHOD FOR INHIBITION OF TUMOR CELL ADHESION, PAIN AND INFLAMMATION<br/>[FR] SOLUTION D'IRRIGATION ET METHODE D'INHIBITION DE L'ADHESION DE CELLULES TUMORALES, DE DOULEURS ET D'INFLAMMATIONS
  申请人：OMEROS CORP

  公开号：WO2004043479A1

  公开（公告）日：2004-05-27

  A method and solution for perioperatively inhibiting tumor cell adhesion and a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes at least one anti-tumor cell adhesion agent and multiple pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit tumor cell adhesion, pain and inflammation includes at least one anti-tumor cell adhesion agent, a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokininl antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykininl antagonist, a bradykinin2 antagonist and a ν-opioid agonist.