6-(2-Sulfanylacetamido)hexanoic acid | 869803-41-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-(2-Sulfanylacetamido)hexanoic acid
• 英文别名: 6-[(2-sulfanylacetyl)amino]hexanoic acid
• CAS: 869803-41-8
• 化学式: C₈H₁₅NO₃S
• 分子量: 205.28
• InChiKey: CTWVBYXJJNKRPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  67.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Mercaptoamides as histone deacetylase inhibitors
  申请人：Ahmed Saleh

  公开号：US20060047123A1

  公开（公告）日：2006-03-02

  Mercaptoamide compounds, represented by Formulas (IA), (IB), (IIA), and (IIB): or a pharmaceutically acceptable salt thereof, inhibit histone deacetylase enzyme and are useful for the treatment and/or prevention of various infections, cancerous diseases, and conditions.

  巯基酰胺化合物，以化学式(IA)、(IB)、(IIA)和(IIB)表示，或其药用盐，抑制组蛋白去乙酰化酶，可用于治疗和/或预防各种感染、癌症疾病和疾病。
• Isoform Selective HDAC Inhibitors
  申请人：Kozikowski Alan P.

  公开号：US20100196502A1

  公开（公告）日：2010-08-05

  One aspect of the invention relates to isoform-selective HDAC inhibitors. Also provided are methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy. The invention also provides methods for treating cancer, methods for treating neurological diseases and methods for treating malaria. Additionally, the invention provides pharmaceutical compositions comprising an HDAC inhibitor of the invention; and kits comprising a an HDAC inhibitor of the invention.

  本发明的一个方面涉及选择性同工酶HDAC抑制剂。还提供了一种使癌细胞对放疗的细胞毒性效应敏感的方法。本发明还提供了治疗癌症、神经系统疾病和疟疾的方法。此外，本发明还提供包含本发明的HDAC抑制剂的制药组合物；以及包含本发明的HDAC抑制剂的试剂盒。
• ISOFORM-SELECTIVE HDAC INHIBITORS
  申请人：Georgetown University

  公开号：EP2049505A2

  公开（公告）日：2009-04-22
• Solid-phase capture-release-tag methods for phosphoproteomic analyses
  申请人：Tseng Huang-Chun

  公开号：US20050261475A1

  公开（公告）日：2005-11-24

  One aspect of the present invention relates to a method of labeling a peptide or protein comprising a phosphorylated amino acid comprising: a) removing from the peptide or protein the phosphate group via a β-elimination to form a double bond conjugated to a C═O group; b) reacting the double bond from step a) with a nucleophile comprising a tag on a solid support; and c) removing the solid support from the product of step b) forming the labeled peptide or protein. A second aspect of the invention relates to a solid support comprising a linker and tag between the solid support and a nucleophile, wherein the tag comprises a label.
• US8653278B2
  申请人：——

  公开号：US8653278B2

  公开（公告）日：2014-02-18