2-Phenyl-1.3-dioxolanon-(4)-diessigsaeure-(5.5)-anhydrid | 87978-70-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Phenyl-1.3-dioxolanon-(4)-diessigsaeure-(5.5)-anhydrid
• 英文别名: 2-phenyl-1,3,8-trioxa-spiro[4.5]decane-4,7,9-trione；2-Phenyl-1,3,8-trioxaspiro[4.5]decane-4,7,9-trione；2-phenyl-1,3,8-trioxaspiro[4.5]decane-4,7,9-trione
• CAS: 87978-70-9
• 化学式: C₁₃H₁₀O₆
• 分子量: 262.219
• InChiKey: SMWPXALECUPFAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] PROTECTED CARBOXYLIC ACID-BASED METABOLITES FOR THE TREATMENT OF DISESASES RELATED TO MITOCHONDRIAL DYSFUNCTIONS<br/>[FR] MÉTABOLITES PROTÉGÉS À BASE D'ACIDE CARBOXYLIQUE POUR LE TRAITEMENT DES MALADIES LIÉES À DES DYSFONCTIONS MITOCHONDRIALES
  申请人：NEUROVIVE PHARMACEUTICAL AB

  公开号：WO2017060400A1

  公开（公告）日：2017-04-13

  The present invention provides novel cell-permeable carboxylic acid- based metabolites and cell permeable precursors thereof aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates from mitochondrial oxidative phosphorylation, a process to which high- energy electrons are provided by the Kreb's cycle. Not all Kreb's cycle intermediates are readily permeable to the cellular membrane. The provision of the novel cell permeable carboxylic acid-based metabolites is envisaged to allow passage over the cellular membrane and thus the cell permeable carboxylic acid-based metabolites can be used to enhance mitochondrial ATP-output.