Benzoic acid, 5-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]-2-hydroxy- | 876903-48-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: Benzoic acid, 5-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]-2-hydroxy-
• 英文别名: 5-[2-formyl-5-(hydroxymethyl)pyrrol-1-yl]-2-hydroxybenzoic acid
• CAS: 876903-48-9
• 化学式: C₁₃H₁₁NO₅
• 分子量: 261.23
• InChiKey: VUXRLABGWNUXQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  99.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Compositions containing 5-amino-2-hydroxybenzoic acid and a reducing sugar
  申请人：Kaczanowski John Matthew

  公开号：US20060046973A1

  公开（公告）日：2006-03-02

  Compositions comprising 5-amino-2-hydroxybenzoic acid (5-amino salicylic acid, mesalamine) and a reducing sugar, e.g., lactose, undergo the Maillard and other chemical reactions and produce, in the case of lactose, a degradant 5-[2-Formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]-2-hydroxybenzoic acid. Inventors have developed means to contain and/or reduce the formation of degradants of 5-amino-2-hydroxybenzoic acid.

  由5-氨基-2-羟基苯甲酸（5-氨基水杨酸，mesalamine）和还原糖（如乳糖）组成的组合物会发生马氏反应和其他化学反应，并在乳糖的情况下产生降解物5-[2-甲酰基-5-(羟甲基)-1H-吡咯-1-基]-2-羟基苯甲酸。发明者已开发出控制和/或减少 5-氨基-2-羟基苯甲酸降解物形成的方法。
• COMPOSITIONS COMPRISING 5-AMINO-2-HYDROXYBENZOIC ACID AND A REDUCING SUGAR
  申请人：The Procter and Gamble Company

  公开号：EP1784166B1

  公开（公告）日：2009-03-04
• Compositions Comprising 5-Amino-2-Hydroxybenzoic Acid and a Reducing Sugar
  申请人：Kaczanowski Matthew John

  公开号：US20100210605A1

  公开（公告）日：2010-08-19

  Compositions comprising 5-amino-2-hydroxybenzoic acid (5-amino salicylic acid, mesalamine) and a reducing sugar, e.g., lactose, undergo the Maillard and other chemical reactions and produce, in the case of lactose, a degradant 5-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]-2-hydroxybenzoic acid. Inventors have developed means to contain and/or reduce the formation of degradants of 5-amino-2-hydroxybenzoic acid.
• STABLE PHARMACEUTICAL COMPOSITIONS OF MESALAMINE
  申请人：CADILA HEALTHCARE LIMITED

  公开号：US20160045442A1

  公开（公告）日：2016-02-18

  The present invention relates to stable pharmaceutical compositions of mesalamine. The composition of the invention is a capsule dosage form filled with a tablet. The invention also relates to process for preparing such compositions. The invention specifically relates to a composition of mesalamine wherein the composition is devoid of any reducing sugar or sugar alcohol.
• [EN] COMPOSITIONS COMPRISING 5-AMINO-2-HYDROXYBENZOIC ACID AND A REDUCING SUGAR<br/>[FR] COMPOSITIONS CONTENANT DE L'ACIDE 5-AMINO-2-HYDROXYBENZOIQUE ET UN SUCRE DE REDUCTION
  申请人：PROCTER & GAMBLE

  公开号：WO2006028831A2

  公开（公告）日：2006-03-16

  Compositions comprising 5-amino-2-hydroxybenzoic acid (5-amino salicylic acid, mesalamine) and a reducing sugar, e.g., lactose, undergo the Maillard and other chemical reactions and produce, in the case of lactose, a degradant 5-[2-Formyl-5-(hydroxymethyl)-1H-pyrrol-1-y]-2-hydroxybenzoic acid. Inventors have developed means to contain and/or reduce the formation of degradants of 5-amino-2-hydroxybenzoic acid.