Oleoyl Serinol | 72809-08-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Oleoyl Serinol
• 英文别名: N-(1,3-dihydroxypropan-2-yl)octadec-9-enamide
• CAS: 72809-08-6
• 化学式: C₂₁H₄₁NO₃
• 分子量: 355.6
• InChiKey: LGDVTFHRZXBSJM-UHFFFAOYSA-N

物化性质

• 溶解度：
  DMF：>30 mg/ml； DMSO：>15 mg/ml；乙醇：>30 mg/ml； PBS（pH 7.2）：>290 μg/ml

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  25
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Compositions and methods for enrichment of neural stem cells using ceramide analogs
  申请人：Condie G Brian

  公开号：US20060014280A1

  公开（公告）日：2006-01-19

  The present invention provides compositions and methods for human neural cell production. More particularly, the present invention provides cellular differentiation methods employing amphiphilic lipid compounds, preferably ceramide analogs of the β-hydroxyalkylamine type and optionally employing an essentially serum free MEDII conditioned medium for the generation of human neural cells from pluripotent human cells. The methods alternatively comprise modulating apoptosis by modifying the levels of PAR-4, with or without the presence of amphiphilic lipid compounds and optionally employing MEDII conditioned medium. The methods alternatively encompass modulating apoptosis by modulating the intracellular concentration of endogenous lipid second messengers, such as ceramide.

  本发明提供了用于人类神经细胞生产的组合物和方法。更具体地说，本发明提供了细胞分化方法，采用两亲脂质化合物，最好是β-羟基烷基胺类神经酰胺类似物，并可选择地采用基本上无血清的MEDII条件培养基，从多能人类细胞中产生人类神经细胞。这些方法还包括通过调节 PAR-4 的水平来调节细胞凋亡，无论是否存在两亲脂质化合物，并可选择使用 MEDII 条件培养基。这些方法还包括通过调节内源性脂质第二信使（如神经酰胺）的细胞内浓度来调节细胞凋亡。
• Method for neural differentiation of embryonic stem cells using protease passaging techniques
  申请人：Schulz C. Thomas

  公开号：US20060183221A1

  公开（公告）日：2006-08-17

  The present invention provides methods for human pluripotent cell culturing and for neural cell production. More particularly, the present invention provides culturing methods employing dissociating cell cultures to an essentially single cell culture, such as by employing antibody selection and bulk passaging treatments utilizing the subsequent application of Collagenase and trypsin. In certain embodiments, the cells are further treated with essentially serum free MEDII conditioned medium, proline, or minimal medium, and are optionally treated with amphiphilic lipid compounds for the generation of human neural cells from pluripotent human cells. In certain embodiments, the cells cultured using these methods have an abnormal karyotype.

  本发明提供了人类多能细胞培养和神经细胞生产的方法。更具体地说，本发明提供了将细胞培养物解离成基本单细胞培养物的培养方法，例如通过抗体选择和随后应用胶原酶和胰蛋白酶的批量传代处理。在某些实施方案中，细胞进一步用基本无血清的 MEDII 条件培养基、脯氨酸或最低限度培养基处理，并可选择用两亲脂质化合物处理，以便从多能人类细胞中生成人类神经细胞。在某些实施方案中，使用这些方法培养的细胞具有异常核型。
• Compositions and Methods for Enrichment of Neural Stem Cells Using Ceramide Analogs
  申请人：Condie Brian G.

  公开号：US20090035285A1

  公开（公告）日：2009-02-05

  The present invention provides compositions and methods for human neural cell production. More particularly, the present invention provides cellular differentiation methods employing amphiphilic lipid compounds, preferably ceramide analogs of the β-hydroxyalkylamine type and optionally employing an essentially serum free MEDII conditioned medium for the generation of human neural cells from pluripotent human cells. The methods alternatively comprise modulating apoptosis by modifying the levels of PAR-4, with or without the presence of amphiphilic lipid compounds and optionally employing MEDII conditioned medium. The methods alternatively encompass modulating apoptosis by modulating the intracellular concentration of endogenous lipid second messengers, such as ceramide.
• Oligodendrocyte Precursor Cell Composition and Methods of Use
  申请人：Bieberich Erhard

  公开号：US20090196859A1

  公开（公告）日：2009-08-06

  The present invention provides a cell culture enriched for sphingolipid enhances neural stem cells (SENSe), particularly oligodendrocyte precursor cells (ODPCs), that do not form teratomas after transplanted in vivo. Methods for producing and use of the invention ODPCs or the cell culture enriched with these ODPCs for stem cell therapy are also provided. The invention method comprises culturing a stem cell culture with a cell culture medium comprising a ceramide compound and a S1P receptor agonist in sequence, overlapping intervals or concurrent manners. The present invention further provides a cellular or gene therapy using a composition comprising a ceramide compound in conjunction with a S1P 1 agonist to proliferate or differentiate endogeneous neural stem cells to ODPCs and further to oligodendrocytes.
• US7445931B2
  申请人：——

  公开号：US7445931B2

  公开（公告）日：2008-11-04