3-异丁氧基-丙酸 | 41255-87-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3-异丁氧基-丙酸
• 英文名称: 3-isobutoxy-propionic acid
• 英文别名: 3-Isobutyloxy-propionsaeure；3-Isobutoxy-propionsaeure；3-(2-Methylpropoxy)propanoic acid
• CAS: 41255-87-2
• 化学式: C₇H₁₄O₃
• mdl: MFCD09950088
• 分子量: 146.186
• InChiKey: QMMGWVCCHWHWEF-UHFFFAOYSA-N

物化性质

• 沸点：
  226.2±23.0 °C(Predicted)
• 密度：
  1.005±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-异丁氧基-丙酸 生成 3-isobutoxy-propionic acid-(4-bromo-phenacyl ester)
  参考文献：
  名称：

  Christian; Hixon, Journal of the American Chemical Society, 1948, vol. 70, p. 1334

  摘要：

  DOI：

文献信息

• DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF
  申请人：Lee Hyun-Joo

  公开号：US20130338179A1

  公开（公告）日：2013-12-19

  The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The diaminopyrimidine derivative or its pharmaceutically acceptable salt functions as a 5-HT 4 receptor agonist, and therefore can be usefully applied for preventing or treating dysfunction in gastrointestinal motility, one of the gastrointestinal diseases, such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, or diabetic gastric atony.

  本发明提供了一种二氨基嘧啶衍生物或其药学上可接受的盐，以及其制备方法、包含相同的药物组合物和使用方法。该二氨基嘧啶衍生物或其药学上可接受的盐作为5-HT4受体激动剂，因此可用于预防或治疗胃肠动力功能障碍等胃肠疾病，如胃食管反流病（GERD）、便秘、肠易激综合征（IBS）、消化不良、术后肠麻痹、胃排空延迟、胃麻痹、肠假性梗阻、药物诱导的肠道传输延迟或糖尿病性胃失神。
• [EN] QUINOXALINES AND AZA-QUINOXALINES AS CRTH2 RECEPTOR MODULATORS<br/>[FR] QUINOXALINES ET AZA-QUINOXALINES COMME MODULATEURS DU RÉCEPTEUR CRTH2
  申请人：MERCK SHARP & DOHME

  公开号：WO2012087861A1

  公开（公告）日：2012-06-28

  The invention provides certain quinoxalines and aza-quinoxalines of the Formula (I), and their pharmaceutically acceptable salts, wherein J1, J2, R1, R2, R3, R22, Ra, Rb, Rc, Rd, X, Y, b, n, and q are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with with uncontrolled or inappropriate stimulation of CRTH2 function.

  该发明提供了式（I）中的某些喹喔啉和氮杂喹喔啉，以及它们的药用盐，其中J1、J2、R1、R2、R3、R22、Ra、Rb、Rc、Rd、X、Y、b、n和q如本文所定义。该发明还提供包含这些化合物的药物组合物，以及使用这些化合物治疗与CRTH2功能的不受控制或不适当刺激相关的疾病或症状的方法。
• (Meth)acryloyl group-containing compound and method for producing the same
  申请人：Nippon Shokubai Co., Ltd.

  公开号：EP1308434A1

  公开（公告）日：2003-05-07

  It is an object of the present invention to provide a compound having a (meth)acryloyl group that is suitably used in various applications, a process for producing such compound simply and under mild conditions, and an useful photo-curable composition and aqueous photo-curable composition comprising such compound. The present invention is related to a process for producing a compound having a (meth)acryloyl group    which comprises reacting a compound having both a (meth) acryloyl group and a vinyl ether group with a compound having at least two functional groups capable of an addition reaction with said vinyl ether group, and to    a compound having a (meth)acryloyl group    which is obtained by an addition reaction of a functional group of a compound (A) having at least two functional groups and the vinyl ether group of a compound (B) having both a (meth)acryloyl group and a vinyl ether group,    said functional groups of said compound (A) being selected from the group consisting of a hydroxyl group, a carboxyl group and a thiol group.

  本发明的目的是提供一种具有(甲基)丙烯酰基的化合物，该化合物可适当地用于各种用途，还提供一种在温和条件下简单生产该化合物的工艺，以及一种有用的光固化组合物和包含该化合物的水性光固化组合物。 本发明涉及一种具有（甲基）丙烯酰基的化合物的生产工艺。 该工艺包括将具有(甲基)丙烯酰基和乙烯基醚基的化合物与具有至少两个能与所述乙烯基醚基发生加成反应的官能团的化合物反应，以及 具有（甲基）丙烯酰基的化合物 该化合物是由具有至少两个官能团的化合物（A）的官能团与具有（甲基）丙烯酰基和乙烯基醚基的化合物（B）的乙烯基醚基发生加成反应而得到的、 所述化合物（A）的官能团选自羟基、羧基和硫醇基组成的组。
• MACROMONOMER FOR PREPARING CEMENT ADMIXTURE AND METHOD FOR PREPARING SAME, AND CEMENT ADMIXTURE COMPRISING POLYCARBOXYLIC ACID COPOLYMER, DERIVED FROM MACROMONOMER, AND LAYERED DOUBLE HYDROXIDE AND METHOD FOR PREPARING SAME
  申请人：Silkroad C&T Co., LTD

  公开号：EP3006423A1

  公开（公告）日：2016-04-13

  Disclosed are a macromonomer for preparing a cement admixture and a method of preparing the same; a cement admixture comprising a polycarboxylic acid-based copolymer derived from the macromonomer and a layered double hydroxide; and a method of preparing the same. The polycarboxylic acid-based copolymer comprises (a) a structural unit derived from a macromonomer compound represented by Formula 1 below and (b) a structural unit derived from an acrylic monomer represented by Formula 4. The cement admixture has superior dispersibility, workability maintenance, and corrosion resistance.         [Formula 1]:     CH2=CR1-(CH2)m-O-(CH2CH2O)n-OCO-R2-COOH         [Formula 4]:     CH2=CR3-COM1

  本发明公开了一种用于制备水泥外加剂的大单体及其制备方法；一种水泥外加剂，该水泥外加剂包括由该大单体和层状双氢氧化物衍生的聚羧酸基共聚物；以及制备该水泥外加剂的方法。聚羧酸基共聚物包括：(a) 由大单体化合物衍生的结构单元，如下式 1 所示；(b) 由丙烯酸单体衍生的结构单元，如下式 4 所示。该水泥外加剂具有优异的分散性、工作性保持性和耐腐蚀性。 [式 1］CH2=CR1-(CH2)m-O-(CH2CH2O)n-OCO-R2-COOH [式 4]：CH2=CR3-COM1
• Diaminopyrimidine derivatives and processes for the preparation thereof
  申请人：YUHAN CORPORATION

  公开号：US10227330B2

  公开（公告）日：2019-03-12

  The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The diaminopyrimidine derivative or its pharmaceutically acceptable salt functions as a 5-HT4 receptor agonist, and therefore can be usefully applied for preventing or treating dysfunction in gastrointestinal motility, one of the gastrointestinal diseases, such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, or diabetic gastric atony.

  本发明提供了一种二氨基嘧啶衍生物或其药学上可接受的盐、其制备工艺、包含二氨基嘧啶衍生物或其药学上可接受的盐的药物组合物及其用途。本发明的二氨基嘧啶衍生物或其药学上可接受的盐具有 5-HT4 受体激动剂的功能，因此可用于预防或治疗胃肠道运动功能障碍，即胃肠道疾病之一、如胃食管反流病（GERD）、便秘、肠易激综合征（IBS）、消化不良、术后回肠梗阻、胃排空延迟、胃瘫、肠假性梗阻、药物引起的转运延迟或糖尿病性胃 弛缓。