N-Methyl-L-alanyl-L-alanine | 61370-50-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Methyl-L-alanyl-L-alanine
• 英文别名: (2S)-2-[[(2S)-2-(methylamino)propanoyl]amino]propanoic acid
• CAS: 61370-50-1
• 化学式: C₇H₁₄N₂O₃
• 分子量: 174.2
• InChiKey: BNOGWBQUPQZAPG-WHFBIAKZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• TEMPLATES FOR NUCLEATION AND PROPAGATION OF PEPTIDE SECONDARY STRUCTURE
  申请人：Prabhakaran Erode N.

  公开号：US20100228004A1

  公开（公告）日：2010-09-09

  Compounds having the Formula I and pharmaceutically acceptable salts thereof are provided in which the variables are described herein. Methods of making the compounds of Formula I are also disclosed.

  提供具有化学式I和其药用可接受盐的化合物，其中变量在此处描述。还公开了制备化学式I化合物的方法。
• Indane-amines as PD-L1 antagonists
  申请人：CHEMOCENTRYX, INC.

  公开号：US11135210B2

  公开（公告）日：2021-10-05

  Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  本研究提供了可用作免疫调节剂的化合物。这些化合物具有式（I） 其中 R1、R2a、R2b、R2c、R3、R4、R5、R6a、R6b、m 和 n 如本文所定义。此外，还公开了与制备和使用此类化合物相关的方法，以及包含此类化合物的药物组合物。
• INDANE-AMINES AS PD-L1 ANTAGONISTS
  申请人：CHEMOCENTRYX, INC.

  公开号：US20200375962A1

  公开（公告）日：2020-12-03

  Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R 1 , R 2a , R 2b , R 2c , R 3 , R 4 , R 5 , R 6a , R 6b , m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
• IMMUNOMODULATOR COMPOUNDS
  申请人：CHEMOCENTRYX, INC.

  公开号：US20210147356A1

  公开（公告）日：2021-05-20

  Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein Z, L, R 1a , R 1b , R 1c , R 1d , R 2a , R 2b , R 2c , R 3 , R 4 , R 5 , R 6a , R 6b , m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
• METHODS OF TREATING CANCER WITH SMALL MOLECULE PD-L1 INHIBITORS
  申请人：CHEMOCENTRYX, INC.

  公开号：US20210236476A1

  公开（公告）日：2021-08-05

  The present disclosure provides, inter alia, methods of treating cancer by administering an effective amount of a com-pound of Formula (I). In some embodiments, the cancer is a solid cancer. In some embodiments, the cancer is melanoma. In some aspects, the present disclosure provides methods of increasing the CD8+ T cell/CD4+ T cell ratio in a solid tumor microenvironment by administering an effective amount of a compound of Formula (I).