2-[2-(Acryloyloxy)ethoxy]ethyl dodecanoate | 61708-51-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-[2-(Acryloyloxy)ethoxy]ethyl dodecanoate
• 英文别名: 2-(2-prop-2-enoyloxyethoxy)ethyl dodecanoate
• CAS: 61708-51-8
• 化学式: C₁₉H₃₄O₅
• 分子量: 342.5
• InChiKey: VDCHTEMAFWYUFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  24
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• NANOPARTICLES CARRYING ANTIBIOTICS
  申请人：TUROS EDWARD

  公开号：US20190133944A1

  公开（公告）日：2019-05-09

  The subject invention pertains to polyacrylate homopolymers produced from acrylolated drug monomers. The homopolymers can be produced in the form of nanoparticles. The nanoparticles comprising the homopolymers can be produced via a free radical-induced emulsion polymerization of the acrylolated drug monomers to produce an aqueous emulsion of uniformly sized nanoparticles. The homopolymers of the invention containing acrylolated antibiotic monomers can be active against Gram-positive and Gram-negative bacteria, such as Staphylococcus aureus and Escherichia coil. Accordingly, methods are provided of treating a disease, for example, an infection, by administering to a subject the homopolymers, homopolymeric nanoparticles, or emulsions containing homopolymeric nanoparticles of the invention.

  本发明涉及从丙烯酰基药物单体制备的聚丙烯酸酯均聚物。这些均聚物可以以纳米粒子的形式制备。通过自由基诱导的乳液聚合反应，可以将丙烯酰基药物单体聚合成均匀大小的纳米粒子的水性乳液。本发明中含有丙烯酰基抗生素单体的均聚物可以对革兰氏阳性和革兰氏阴性细菌具有活性，例如金黄色葡萄球菌和大肠杆菌。因此，本发明提供了通过向受体施用本发明中的均聚物、均聚纳米粒子或含有均聚纳米粒子的乳液来治疗疾病，例如感染的方法。
• Nanoparticles carrying antibiotics
  申请人：UNIVERSITY OF SOUTH FLORIDA

  公开号：US11116725B2

  公开（公告）日：2021-09-14

  The subject invention pertains to polyacrylate homopolymers produced from acrylolated drug monomers. The homopolymers can be produced in the form of nanoparticles. The nanoparticles comprising the homopolymers can be produced via a free radical-induced emulsion polymerization of the acrylolated drug monomers to produce an aqueous emulsion of uniformly sized nanoparticles. The homopolymers of the invention containing acrylolated antibiotic monomers can be active against Gram-positive and Gram-negative bacteria, such as Staphylococcus aureus and Escherichia coil. Accordingly, methods are provided of treating a disease, for example, an infection, by administering to a subject the homopolymers, homopolymeric nanoparticles, or emulsions containing homopolymeric nanoparticles of the invention.

  本发明涉及用丙烯醇化药物单体生产的聚丙烯酸酯均聚物。这种均聚物可以纳米颗粒的形式生产。由该均聚物组成的纳米颗粒可通过丙烯醇化药物单体的自由基诱导乳液聚合来生产，从而产生大小均匀的纳米颗粒水乳液。本发明含有丙烯醇化抗生素单体的均聚物可对革兰氏阳性和革兰氏阴性细菌（如金黄色葡萄球菌和卷曲杆菌）具有活性。因此，提供了通过向受试者施用本发明的均聚物、均聚纳米粒子或含有均聚纳米粒子的乳液来治疗疾病（例如感染）的方法。
• NANOPARTICLES WITH COVALENTLY BOUND SURFACTANT FOR DRUG DELIVERY
  申请人：Turos Edward

  公开号：US20130071348A1

  公开（公告）日：2013-03-21

  The present invention concerns nanoparticles, compositions comprising the nanoparticles, methods for their production, and methods of using the nanoparticles for the delivery of biologically active agents (e.g., antibiotics or other drugs) to human or non-human subjects. In one embodiment, the nanoparticle is a “surfactant-free” nanoparticle in which the surfactant moiety is covalently attached to the backbone of the polymer.
• US8414926B1
  申请人：——

  公开号：US8414926B1

  公开（公告）日：2013-04-09