N-[(1S,2S)-2-Hydroxycyclopentyl]-3-oxododecanamide | 669721-37-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-[(1S,2S)-2-Hydroxycyclopentyl]-3-oxododecanamide
• 英文别名: N-[(1S,2S)-2-hydroxycyclopentyl]-3-oxododecanamide
• CAS: 669721-37-3
• 化学式: C₁₇H₃₁NO₃
• 分子量: 297.4
• InChiKey: RKYZEJJZFJEGAZ-HOTGVXAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Combinatorial libraries of autoinducer analogs, autoinducer agonists and antagonists, and methods of use thereof
  申请人：——

  公开号：US20040115732A1

  公开（公告）日：2004-06-17

  The present invention relates to solid phase or solution phase combinatorial libraries of autoinducer analogs. The present invention also relates to autoinducer agonists and antagonists. In addition, the present invention relates to methods for identifying autoinducer agonists and antagonists, as well as methods for regulating the activity of an autoinducer receptor, regulating biofilm formation, regulating growth or virulence of an organism in a subject, inhibiting the quorum sensing mechanism of an organism, and treating an infection in a subject caused by an organism possessing a quorum sensing mechanism which use the autoinducer analogs of the present invention.

  本发明涉及自感应剂类似物的固相或溶液相组合库。本发明还涉及自感应剂和拮抗剂。此外，本发明还涉及识别自感应剂和拮抗剂的方法，以及调节自感应受体的活性、调节生物膜形成、调节生物体在主体中的生长或毒力、抑制生物体的群体感应机制，并使用本发明的自感应剂类似物治疗由具有群体感应机制的生物体引起的主体感染。
• COMBINATORIAL LIBRARIES OF AUTOINDUCER ANALOGS, AUTOINDUCER AGONISTS AND ANTAGONISTS, AND METHODS OF USE THEREOF
  申请人：SUGA Hiroaki

  公开号：US20080027115A1

  公开（公告）日：2008-01-31

  The present invention relates to solid phase or solution phase combinatorial libraries of autoinducer analogs. The present invention also relates to autoinducer agonists and antagonists. In addition, the present invention relates to methods for identifying autoinducer agonists and antagonists, as well as methods for regulating the activity of an autoinducer receptor, regulating biofilm formation, regulating growth or virulence of an organism in a subject, inhibiting the quorum sensing mechanism of an organism, and treating an infection in a subject caused by an organism possessing a quorum sensing mechanism which use the autoinducer analogs of the present invention.

  本发明涉及自感应物类似物的固相或溶液相组合库。本发明还涉及自感应物激动剂和拮抗剂。此外，本发明还涉及识别自感应物激动剂和拮抗剂的方法，以及调节自感应物受体活性、调节生物膜形成、调节在受体中生物体的生长或毒力、抑制生物体的群体感应机制、以及使用本发明的自感应物类似物治疗由具有群体感应机制的生物体引起的受体感染的方法。
• US7498292B2
  申请人：——

  公开号：US7498292B2

  公开（公告）日：2009-03-03
• [EN] COMBINATORIAL LIBRARIES OF AUTOINDUCER ANALOGS, AUTOINDUCER AGONISTS AND ANTAGONISTS, AND METHODS OF USE THEREOF<br/>[FR] BIBLIOTHEQUES COMBINATOIRES D'ANALOGUES AUTOINDUCTEURS, D'AGONISTES ET D'ANTAGONISTES AUTOINDUCTEURS, ET LEURS PROCEDES D'UTILISATION
  申请人：UNIV NEW YORK STATE RES FOUND

  公开号：WO2004016213A2

  公开（公告）日：2004-02-26

  The present invention relates to solid phase or solution phase combinatorial libraries of autoinducer analogs. The present invention also relates to autoinducer agonists and antagonists. In addition, the present invention relates to methods for identifying autoinducer agonists and antagonists, as well as methods for regulating the activity of an autoinducer receptor, regulating biofilm formation, regulating growth or virulence of an organism in a subject, inhibiting the quorum sensing mechanism of an organism, and treating an infection in a subject caused by an organism possessing a quorum sensing mechanism which use the autoinducer analogs of the present invention.