N-methylpropenoyl-L-cysteine | 45014-12-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-methylpropenoyl-L-cysteine
• 英文别名: N-methacryloyl-(l)-cysteine；methacryloyl-cysteine；N-(2-Methylacryloyl)-L-cysteine；(2R)-2-(2-methylprop-2-enoylamino)-3-sulfanylpropanoic acid
• CAS: 45014-12-8
• 化学式: C₇H₁₁NO₃S
• 分子量: 189.235
• InChiKey: JYTWVUNNPDTDQA-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  67.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  L-半胱氨酸 、 甲基丙烯酰氯 在 potassium carbonate 、 sodium nitrite 作用下， 以 水 为溶剂， 反应 2.0h， 生成 N-methylpropenoyl-L-cysteine
  参考文献：
  名称：

  新型氧化还原氧化石墨烯/银纳米立方体杂化印迹聚合物的电催化纳米复合材料，用于痕量替莫唑胺的超痕量传感†

  摘要：

  开发了一种新的纳米复合材料，用于在丝网印刷的碳电极表面上修饰的氧化石墨烯/银纳米立方体杂化的分子印迹聚合物，用于超痕量电分析抗癌药物替莫唑胺。为此，通过同时还原Ag +和氧化石墨烯成功地获得了还原的氧化石墨烯/银纳米立方体的杂化物。简单的一锅绿色合成。在压印聚合物合成中使用的各种形状的纳米材料中，从SEM，TEM和X射线衍射方法可以明显看出，银纳米立方体具有较高的表面体积比和较高的电催化活性。在本文中，还原的氧化石墨烯和银纳米立方体的协同电催化作用被用于减少分析物的氧化超电势，由于涂层的多孔质地，在压印的薄膜和电极表面之间没有任何界面障碍。因此，与简单的氧化石墨烯修饰的传感器相比，在还原的氧化石墨烯/银纳米立方体杂化物上获得了约3倍的差分脉冲阳极剥离电流和约5倍的电子传输速率动力学。共价的Ag–S链接 在压印的薄膜和装饰有银纳米立方体的丝网印刷碳电极之间，对于赋予薄膜涂层更高的稳定性至关重

  DOI：

  10.1039/c8nj01824c

文献信息

• THERMO-RESPONSIVE HYDROGEL COMPOSITIONS
  申请人：KANG-MIELER Jennifer J.

  公开号：US20120231072A1

  公开（公告）日：2012-09-13

  A thermo-responsive hydrogel, including a biocompatible monomer and/or polymer having an amino acid side chain. The hydrogel is thermo-responsive at a physiological temperature, and can include, incorporate, or encapsulate a treatment agent, such as a drug composition, a biomolecule, and/or a nanoparticle. The hydrogel is useful in delivering the treatment agent. The hydrogel is in a first physicochemical state for administration to a mammal. The hydrogel is thermo-responsive at a physiological temperature of the mammal, and changes to a second physicochemical state that is more solid than the first physicochemical state. In the second physicochemical state the thermo-responsive hydrogel releases the treatment agent.

  一种热响应性水凝胶，包括具有氨基酸侧链的生物相容性单体和/或聚合物。该水凝胶在生理温度下具有热响应性，可以包含、结合或封装治疗剂，如药物组合物、生物分子和/或纳米颗粒。该水凝胶在传递治疗剂方面很有用。该水凝胶处于第一物理化学状态以用于哺乳动物。该水凝胶在哺乳动物的生理温度下具有热响应性，并转变为比第一物理化学状态更固体的第二物理化学状态。在第二物理化学状态下，热响应性水凝胶释放治疗剂。
• Imprinted polymer and method for preparing the same
  申请人：Universite De Toulon

  公开号：US10683378B2

  公开（公告）日：2020-06-16

  An imprinted polymer that is not electrically conductive is obtained by polymerization of at least one monomer with at least one crosslinking agent in the presence of a target. The polymer has in its structure at least one cavity having the shape of a target and at least one redox probe assuming either a polymerizable form or a non-polymerizable form. Methods are for preparing an imprinted polymer, for detecting a target implementing such a polymer. The polymer is used as a sensor, and more particularly an imprinted sensor, an active interface to manufacture electrochemical (bio)sensors, or to manufacture solid-phase extraction substrates.

  一种不导电的压印聚合物是通过至少一种单体与至少一种交联剂在目标物存在的情况下进行聚合而得到的。聚合物的结构中至少有一个具有目标物形状的空腔和至少一个可聚合或不可聚合的氧化还原探针。制备压印聚合物的方法，以及用这种聚合物检测目标物的方法。这种聚合物可用作传感器，特别是压印传感器，也可用作制造电化学（生物）传感器或制造固相萃取基质的活性界面。
• POLYMÈRE À EMPREINTE ET PROCÉDÉ DE PRÉPARATION
  申请人：Université de Toulon

  公开号：EP2935376A1

  公开（公告）日：2015-10-28
• Photosensitive Aminoacid-Monomer Linkage and Bioconjugation Applications in Life Sciences and Biotechnology
  申请人：Ersoz Arzu

  公开号：US20110311505A1

  公开（公告）日：2011-12-22

  This invention is related to preparation of photosensitive ruthenium based aminoacid monomers and oligomers, aminoacid monomer-protein cross-linking using photo sensitat ion and conjugation on micro and nano-structures by ruthenium-chelate based monomers. Its vast range biotechnolgy applications of multifunctional, biocompatible, stabilE and specific micro and nanobio-conjugates, which will stand-alone or simultaneously enable (i) both purification and determination, (ii) both targeting and imaging and theranostics and (iii) catalysis and determination. The construction and method of preparation is applicable to silica materials, superparamagnetic particles, QDs, CNTs, Ag/Au nanoparticles and Au surfaces and polymeric materials. The photosensitive aminoacid monomer linkers can react via chemically and biocompatible to a lot of different micro and nano-surface and then to the protein when they act as a single-step cross-linking reaction using irradiation. The photosensitive conjugation based on click biochemistry can be carried out at mild conditions, independent of pH and temperature, without affecting conformation and function of protein.
• IMPRINTED POLYMER AND METHOD FOR PREPARING THE SAME
  申请人：UNIVERSITE DE TOULON

  公开号：US20150344607A1

  公开（公告）日：2015-12-03

  An imprinted polymer that is not electrically conductive is obtained by polymerization of at least one monomer with at least one crosslinking agent in the presence of a target. The polymer has in its structure at least one cavity having the shape of a target and at least one redox probe assuming either a polymerizable form or a non-polymerizable form. Methods are for preparing an imprinted polymer, for detecting a target implementing such a polymer. The polymer is used as a sensor, and more particularly an imprinted sensor, an active interface to manufacture electrochemical (bio)sensors, or to manufacture solid-phase extraction substrates.