申请人:——
公开号:US20040013614A1
公开(公告)日:2004-01-22
An Adhesive composition for us in surgery, especially ophthalmic surgery, comprises a mixture of a cyanoacrylate of general formula (I) and an acrylate compound of formula (II) where R4 is an alkylene group and Y is a cycloalkyl group or Y═OR where R═H or acryloyl. It is found that compositions of this type have a number of advantages over simple cyanoacrylate adhesives, including: (a) a longer cure time, allowing easier handling of the joint; (b) a more flexible cured product; (c) a tendency for the cured to come away from the tissue after a month or so thus facilitating healing; and (d) a substantially non-exothermic curing reaction, thereby avoiding thermal damage to the tissue.
1
一种用于手术,特别是眼科手术的粘合剂组合物,包括一种通式(I)的氰基丙烯酸酯和一种式(II)的丙烯酸酯化合物的混合物,其中R4是一种烷基基团,Y是一个环烷基团或Y═OR,其中R═H或丙烯酰基。发现这种类型的组合物比单纯的氰基丙烯酸酯粘合剂具有许多优点,包括:(a)较长的固化时间,使接头更易于处理;(b)固化后的产品更具有弹性;(c)固化后易于从组织中脱离,从而促进愈合;和(d)固化反应基本上是非放热的,从而避免对组织的热损伤。1