4-methyl-6-(2-pyridyl)-5-aza-4-hexen-2-one | 28484-27-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-methyl-6-(2-pyridyl)-5-aza-4-hexen-2-one
• 英文别名: (4E)-4-{[(Pyridin-2-yl)methyl]imino}pentan-2-one；4-(pyridin-2-ylmethylimino)pentan-2-one
• CAS: 28484-27-7
• 化学式: C₁₁H₁₄N₂O
• 分子量: 190.245
• InChiKey: OCLWTLYSPQYSHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  42.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-methyl-6-(2-pyridyl)-5-aza-4-hexen-2-one 在 NaOCH₃ 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 为溶剂， 生成
  参考文献：
  名称：

  氯[2-（α-piclylyinoino）-4-pentanonato]钯（II）衍生的有机钯配合物和由活性亚甲基化合物形成的碳负离子

  摘要：

  制备了一种新的络合物，氯[2-（α-piclylyinoino）-4-戊烷酮]钯（II），并用由活性亚甲基化合物形成的一些碳负离子处理。在丙二酸二甲酯，氰基乙酸烷基酯和丙二腈的情况下，在氯气中的亲核取代反应提供了新的稳定的配合物，该配合物包含钯-碳键。这些络合物的特征在于其红外光谱，1 H和13 C NMR光谱以及电导率。

  DOI：

  10.1016/s0022-328x(00)94407-3
• 作为产物：
  描述：

  2-氨甲基吡啶 、 乙酰丙酮 以 甲醇 为溶剂， 反应 2.0h， 生成 4-methyl-6-(2-pyridyl)-5-aza-4-hexen-2-one
  参考文献：
  名称：

  Effect of ligand substitution on DNA binding ability of two new square planar copper(II)–Schiff base complexes

  摘要：

  Two terdentate NNO donor Schiff base ligands CH3C(OH=CHC(CH3)=NCH2C5H4N [HL1] and C6H5C(OH)=CHC(CH3)=NCH2C5H4N [HL2] were used to synthesize two mononuclear square planar copper(II) complexes, [CuL1(CF3COO)] (1) and [CuL2(CF3COO)] (2). The complexes were characterized by elemental analyses, FT-IR, UV-vis spectral methods and their structures were established by single crystal X-ray diffraction study. The biochemical activity of the complexes towards DNA binding were performed using absorbance and fluorescence titration methods and their mode of binding with calf thymus DNA has been established by viscosity measurement technique. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2010.04.034

文献信息

• Synthesis of an iron(ii) complex versatile for preparation of iron(ii) complexes with novel pentadentate ligands via C–C bond formation with various nitriles: 1,3-dimethyl-1,3-propanediylidenebis(2-pyridylmethanamine)iron(ii) perchlorate
  作者：Masafumi Goto、Yoshinobu Ishikawa、Takao Ishihara、Chika Nakatake、Tomoe Higuchi、Hiromasa Kurosaki、the late Virgil L. Goedken

  DOI：10.1039/a700283a

  日期：——

  A bis(acetonitrile)iron(II) complexes with 1,3-dimethyl-1,3-propanediylidenebis(2-pyridylmethanamine) undergoes a nucleophilic addition to the nitrile carbon on addition of triethylamine to a nitrile solution yielding mono(acetoni-trile)iron(II) complex with a novel pentadentate polyimine ligand.
• Maeda, Yonezo; Oshio, Hiroki; Takashima, Yoshimasa, Inorganic Chemistry, <hi>1986</hi>, vol. 25, # 17, p. 2958 - 2962
  作者：Maeda, Yonezo、Oshio, Hiroki、Takashima, Yoshimasa、Mikuriya, Masahiro、Hidaka, Masanori

  DOI：——

  日期：——
• Maeda, Yonezo; Tsutsumi, Naoto; Takashima, Yoshimasa, Inorganic Chemistry, <hi>1984</hi>, vol. 23, # 16, p. 2440 - 2447
  作者：Maeda, Yonezo、Tsutsumi, Naoto、Takashima, Yoshimasa

  DOI：——

  日期：——
• Organopalladium complexes derived from chloro[2-(α-picolylimino)-4-pentanonato]palladium(II) and carbanions formed from active methylene compounds
  作者：Katsuma Hiraki、Masayoshi Onishi、Hiroshi Matsuo

  DOI：10.1016/s0022-328x(00)94407-3

  日期：1980.1

  A new complex, chloro[2-(α-picolylimino)-4-pentanonato] palladium(II) was prepared, and treated with some carbanions formed from active methylene compounds. Nucleophilic displacement reactions at chlorine afforded new stable complexes containing a palladium—carbon bond in the case of dimethyl malonate, alkyl cyanoacetates, and malononitrile. These complexes were characterized by their IR spectra, 1H

  制备了一种新的络合物，氯[2-（α-piclylyinoino）-4-戊烷酮]钯（II），并用由活性亚甲基化合物形成的一些碳负离子处理。在丙二酸二甲酯，氰基乙酸烷基酯和丙二腈的情况下，在氯气中的亲核取代反应提供了新的稳定的配合物，该配合物包含钯-碳键。这些络合物的特征在于其红外光谱，1 H和13 C NMR光谱以及电导率。
• Effect of ligand substitution on DNA binding ability of two new square planar copper(II)–Schiff base complexes
  作者：Dipali Sadhukhan、Aurkie Ray、Saurabh Das、Corrado Rizzoli、Georgina M. Rosair、Samiran Mitra

  DOI：10.1016/j.molstruc.2010.04.034

  日期：2010.6

  Two terdentate NNO donor Schiff base ligands CH3C(OH=CHC(CH3)=NCH2C5H4N [HL1] and C6H5C(OH)=CHC(CH3)=NCH2C5H4N [HL2] were used to synthesize two mononuclear square planar copper(II) complexes, [CuL1(CF3COO)] (1) and [CuL2(CF3COO)] (2). The complexes were characterized by elemental analyses, FT-IR, UV-vis spectral methods and their structures were established by single crystal X-ray diffraction study. The biochemical activity of the complexes towards DNA binding were performed using absorbance and fluorescence titration methods and their mode of binding with calf thymus DNA has been established by viscosity measurement technique. (C) 2010 Elsevier B.V. All rights reserved.