Gly Gly Gly Gly Gly Gly Ser | 181724-81-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Gly Gly Gly Gly Gly Gly Ser
• 英文别名: Gly · Gly · Gly · Gly · Gly · Gly · Ser；Glycylglycylglycylglycylglycylglycyl-L-serine；(2S)-2-[[2-[[2-[[2-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]-3-hydroxypropanoic acid
• CAS: 181724-81-2
• 化学式: C₁₅H₂₅N₇O₉
• 分子量: 447.405
• InChiKey: PJFMRHQCCYAMBT-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8
• 重原子数：
  31
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  258
• 氢给体数：
  9
• 氢受体数：
  10

文献信息

• RNA viruses expressing IL-12 for immunovirotherapy
  申请人：DEUTSCHES KREBSFORSCHUNGSZENTRUM

  公开号：US10344067B2

  公开（公告）日：2019-07-09

  The present invention relates to a recombinant virus of the family Paramyxoviridae, comprising at least one expressible polynucleotide encoding an IL-12 polypeptide, wherein said IL-12 polypeptide is an IL-12 fusion polypeptide comprising a p35 subunit of an IL-12 and a p40 subunit of an IL-12; to a polynucleotide encoding the same, and to a kit comprising the same. Moreover, the present invention relates to a method for treating cancer in a subject afflicted with cancer, comprising contacting said subject with a recombinant virus of the family Paramyxoviridae of the invention, and thereby, treating cancer in a subject afflicted with cancer.

  本发明涉及一种副粘病毒科重组病毒，其包含至少一种编码IL-12多肽的可表达多核苷酸，其中所述IL-12多肽是IL-12融合多肽，其包含IL-12的p35亚基和IL-12的p40亚基；本发明还涉及编码本发明的多核苷酸以及包含本发明的试剂盒。此外，本发明还涉及一种治疗癌症患者癌症的方法，包括使所述患者与本发明的副粘病毒科重组病毒接触，从而治疗癌症患者的癌症。
• RNA VIRUSES EXPRESSING IL-12 FOR IMMUNOVIROTHERAPY
  申请人：DEUTSCHES KREBSFORSCHUNGSZENTRUM

  公开号：US20170247425A1

  公开（公告）日：2017-08-31

  The present invention relates to a recombinant virus of the family Paramyxoviridae, comprising at least one expressible polynucleotide encoding an IL-12 polypeptide, wherein said IL-12 polypeptide is an IL-12 fusion polypeptide comprising a p35 subunit of an IL-12 and a p40 subunit of an IL-12; to a polynucleotide encoding the same, and to a kit comprising the same. Moreover, the present invention relates to a method for treating cancer in a subject afflicted with cancer, comprising contacting said subject with a recombinant virus of the family Paramyxoviridae of the invention, and thereby, treating cancer in a subject afflicted with cancer.