(2S)-2-amino-4-(propylsulfonimidoyl)butanoic acid | 156714-62-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-amino-4-(propylsulfonimidoyl)butanoic acid
• CAS: 156714-62-4
• 化学式: C₇H₁₆N₂O₃S
• 分子量: 208.28
• InChiKey: NNDIRXUEVHPTNF-YLTHGKPTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Anti-microbial agents derived from methionine sulfoximine analogues
  申请人：——

  公开号：US20040157802A1

  公开（公告）日：2004-08-12

  Novel antimicrobial compositions containing analogues of L-methionine-SR-sulfoximine (MSO) that are effective in treating intracellular pathogen infections are provided. Specifically, the compostions provided are MSO analogues having superior antimicrobial activity with significantly less toxicity as compared to MSO. These MSO analogues are suitable for use in treating infection in animals including primates, cows, pigs, horses, rabbits, mice, rats, cats, and dogs. Moreover, the MSO analogues are ideally suited for treating infections caused by the genus Mycobacterium. Additionally, methods for using the novel MSO analogues are also provided.

  本研究提供了含有可有效治疗细胞内病原体感染的 L-蛋氨酸-SR-亚磺酰亚胺（MSO）类似物的新型抗菌组合物。具体来说，所提供的组合物是 MSO 类似物，与 MSO 相比，其抗菌活性更强，毒性更低。这些 MSO 类似物适用于治疗动物感染，包括灵长类动物、牛、猪、马、兔、小鼠、大鼠、猫和狗。此外，MSO 类似物非常适合治疗由分枝杆菌属引起的感染。此外，还提供了使用新型 MSO 类似物的方法。
• [EN] ANTI-MICROBIAL AGENTS DERIVED FROM METHIONINE SULFOXIMINE ANALOGUES<br/>[FR] AGENTS ANTIMICROBIENS DERIVES DE LA METHIONINE SULFOXIMINE
  申请人：UNIV CALIFORNIA

  公开号：WO2004045539A2

  公开（公告）日：2004-06-03

  Novel antimicrobial compositions containing analogues of L-methionine-SR-sulfoximine (MSO) that are effective in treating intracellular pathogen infections are provided. Specifically, the compositions provided are MSO analogues having superior antimicrobial activity with significantly less toxicity as compared to MSO. These MSO analogues are suitable for use in treating infection in animals including primates, cows, pigs, horses, rabbits, mice, rats, cats, and dogs. Moreover, the MSO analogues are ideally suited for treating infections caused by the genus Mycobacterium. Additionally, methods for using the novel MSO analogues are also provided.