3-氨基-4-苯基-2-丁酮 | 40513-35-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-氨基-4-苯基-2-丁酮
• 中文别名: 3-氨基-4-苯基丁-2-酮
• 英文名称: 3-amino-4-phenyl-butan-2-one
• 英文别名: 3-Amino-4-phenyl-butan-2-on；α-Amino-α-benzyl-aceton；3-Amino-4-phenyl-2-butanon；3-Amino-4-phenylbutan-2-one
• CAS: 40513-35-7
• 化学式: C₁₀H₁₃NO
• mdl: MFCD06357369
• 分子量: 163.219
• InChiKey: RTUDQBPZFFIRAD-UHFFFAOYSA-N

物化性质

• 熔点：
  130 °C
• 沸点：
  261.6±28.0 °C(Predicted)
• 密度：
  1.043±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-氨基-4-苯基-2-丁酮 在 盐酸 、 sodium amalgam 作用下， 生成 amino-3 phenyl-4 butanol-2
  参考文献：
  名称：

  NITROGEN TRICHLORIDE AND UNSATURATED KETONES. II

  摘要：

  DOI：

  10.1021/ja01393a052
• 作为产物：
  描述：

  tert-butyl (1-(methoxy(methyl)amino )-1-oxo-3-phenylpropan-2-yl)carbamate 在 三氟乙酸 作用下， 生成 3-氨基-4-苯基-2-丁酮
  参考文献：
  名称：

  Peptide inhibitors of IKB protease: Modification of the C-termini of Z-LLF-CHO

  摘要：

  A series of tripeptides (Z-LLF-R) with various modifications at their C-terminus were synthesized and evaluated for their ability to prevent the activation of NF-kappa B through inhibition of I kappa B protease. Of the compounds evaluated only the C-terminal aldehydes 5a,b were active in our Jurkat T-cell based assay. Compound 5a also decreased IL-2 and IL-8 levels in these cells indicating that inhibitors of I kappa B protease can have an effect on various signaling pathways. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00559-8

文献信息

• [EN] BICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY<br/>[FR] COMPOSÉS HÉTÉROARYLE BICYCLIQUES UTILES EN TANT QU'INHIBITEURS DE LA VOIE DE SIGNALISATION PAR-2
  申请人：VERTEX PHARMA

  公开号：WO2016154075A1

  公开（公告）日：2016-09-29

  The compounds of formula I, wherein the variables are as defined herein, and pharmaceutically acceptable salts thereof are useful as inhibitors of the PAR-2 signaling pathway. The compounds of formula I and pharmaceutically acceptable compositions comprising such compounds can be employed for treating various diseases, disorders, and conditions.

  式I的化合物，其中变量如本文所定义，并且其药学上可接受的盐可用作PAR-2信号通路的抑制剂。式I的化合物和包含这些化合物的药学上可接受的组合物可用于治疗各种疾病、疾病和症状。
• DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID
  申请人：Fleming Paul E.

  公开号：US20110245203A1

  公开（公告）日：2011-10-06

  The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

  本发明提供了作为蛋白酶体抑制剂有用的新化合物。该发明还提供了包括该发明化合物的药物组合物，以及在治疗各种疾病中使用这些组合物的方法。
• Dextran functionalized by hydrophobic amino acids
  申请人：Soula Gerard

  公开号：US20080234227A1

  公开（公告）日：2008-09-25

  The invention relates to a dextran functionalized by at least one hydrophobic alpha-amino acid radical, said alpha-amino acid being grafted or bonded to the dextran by a bonding arm and a functional group. A hydrophobic amino acid radical is understood as being the product of coupling between the amine of the amino acid and an acid carried by the bonding arm, said dextran being amphiphilic at neutral pH. In an embodiment, the hydrophobic amino acid is selected from tryptophan derivatives, such as tryptophan, tryptophanol, tryptophanamide, 2-indole ethyl-amine and their alkaline cation salts. The present invention relates also to a pharmaceutical composition comprising one of the dextrans according to the invention.

  该发明涉及至少一个疏水性α-氨基酸基团功能化的葡聚糖，所述α-氨基酸通过一个连接臂和一个功能基团被嫁接或结合到葡聚糖上。疏水性氨基酸基团被理解为氨基酸的胺基与连接臂携带的酸之间的偶联产物，所述葡聚糖在中性pH下为两性的。在一种实施例中，疏水性氨基酸来自色氨酸衍生物，例如色氨酸、色氨醇、色氨酰胺、2-吲哚乙基胺及其碱性阳离子盐。本发明还涉及包含根据本发明的葡聚糖之一的药物组合物。
• [EN] SOLID ORAL DOSAGE FORMS OF 2R,6R-HYDROXYNORKETAMINE OR DERIVATIVES THEREOF<br/>[FR] FORMES POSOLOGIQUES SOLIDES ORALES DE 2R, 6R-HYDROXYNORKÉTAMINE OU LEURS DÉRIVÉS
  申请人：SMALL PHARMA LTD

  公开号：WO2017208031A1

  公开（公告）日：2017-12-07

  This invention relates to solid oral dosage forms of 2R,6R-hydroxynorketamine or prodrugs thereof having Formula Ib, including any pharmaceutically acceptable salt of the foregoing, for use in a therapeutic method for the treatment of a depressive disorder in a patient.

  这项发明涉及具有公式Ib的2R,6R-羟基诺可胺或其前药的固体口服剂型，包括上述任何药用可接受盐，用于治疗患者的抑郁症的治疗方法。
• METHOD FOR THE SYNTHESIS OF SOLID HETEROGENEOUS CHIRAL CATALYSTS AND THEIR USE IN STEREOSELECTIVE REACTIONS
  申请人：Universidad De Guanajuato

  公开号：US20140213796A1

  公开（公告）日：2014-07-31

  This invention describes the methodology to produce solid heterogeneous chiral organocatalysts that can be used in condensation reactions. The catalysts can be recovered in a simple manner by filtration and can also be reused.

  这项发明描述了一种生产固态非均相手性有机催化剂的方法，可用于缩合反应。该催化剂可以通过过滤简单地回收，并且可以重复使用。