3-氨基-5-氟-1H-吡唑 | 1159196-53-8

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 中文名称: 3-氨基-5-氟-1H-吡唑
• 中文别名: 5-氟-1H-吡唑-3-胺
• 英文名称: 3-fluoro-1H-pyrazol-5-amine
• 英文别名: 5-fluoro-1H-pyrazol-3-amine
• CAS: 1159196-53-8
• 化学式: C₃H₄FN₃
• mdl: MFCD22571626
• 分子量: 101.083
• InChiKey: NHAGRTARAUTNOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-氨基-5-氟-1H-吡唑 、 丙炔酸甲酯 在 caesium carbonate 作用下， 以 乙醇 为溶剂， 以61%的产率得到2-fluoropyrazolo[1,5-a]pyrimidin-5-ol
  参考文献：
  名称：

  取代的吡唑并[1,5-a]嘧啶化合物及其用途

  摘要：

  本发明公开了一种取代的吡唑并[1,5‑a]嘧啶化合物及其用途。本发明所公开的式I化合物具有吡唑并[1,5‑a]嘧啶系列结构，对于原肌球蛋白受体(Trk)激酶具有良好的抑制效果，对体外肿瘤细胞增殖也具有良好的抑制作用。

  公开号：

  CN113563343B

文献信息

• [EN] CYCLIC COMPOUNDS AND METHODS OF USING SAME<br/>[FR] COMPOSÉS CYCLIQUES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：SCHRODINGER INC

  公开号：WO2021134004A1

  公开（公告）日：2021-07-01

  The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof which are MALT1 inhibitors. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for treating diseases, such as cancer, autoimmune disorders, and inflammatory disorders.

  本申请涉及以下式（I）的化合物及其药用盐，其在此处定义为MALT1抑制剂。本申请还描述了包括式（I）化合物及其药用盐的药物组合物，以及使用这些化合物和组合物治疗疾病（如癌症、自身免疫性疾病和炎症性疾病）的方法。
• [EN] 2-FLUOROPYRAZOLO[1,5-A]PYRIMIDINES AS PROTEIN KINASE INHIBITORS<br/>[FR] 2-FLUOROPYRAZOLO[1,5-A] PYRIMIDINES EN TANT QU'INHIBITEURS DE PROTÉINE KINASE
  申请人：SCHERING CORP

  公开号：WO2009070567A1

  公开（公告）日：2009-06-04

  Pyrazolo[1,5-a]pyrimidine-based inhibitors of various kinase, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions that contain such inhibitors are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 or CHK-1 inhibitor compounds, methods of inhibiting CDK-2 or CHK-1, and methods for treating disease or disease symptoms.

  基于吡唑并[1,5-a]嘧啶的各种激酶抑制剂，包括这些抑制剂的组合物，以及使用这些抑制剂和抑制剂组合物的方法。含有这些抑制剂的组合物对于治疗疾病或疾病症状是有用的。该发明还提供了制备CDK-2或CHK-1抑制剂化合物的方法，抑制CDK-2或CHK-1的方法，以及治疗疾病或疾病症状的方法。
• [EN] NOVEL PYRAZOLO PYRIMIDINE DERIVATIVES AND THEIR USE AS MALT1 INHIBITORS<br/>[FR] NOUVEAUX DÉRIVÉS PYRAZOLO-PYRIMIDINE ET LEUR UTILISATION COMME INHIBITEURS DE MALT1
  申请人：NOVARTIS AG

  公开号：WO2015181747A1

  公开（公告）日：2015-12-03

  The present invention describes new pyrazolo-pyrimidine derivatives of formula (I) or a pharmaceutically acceptable salt thereof; (I) wherein, R1 is halogen, cyano, or C1-C3alkyl optionally substituted by halogen; R2 is C1-C6alkyl optionally substituted one or more times by C1-C6alkyl, C2-C6alkenyl, hydroxyl, N,N-di-C1-C6alkyl amino, N-mono-C1-C6alkyl amino, O-Rg, Rg, phenyl, or by C1-C6alkoxy wherein said alkoxy again may optionally be substituted by C1-C6alkoxy, N,N-di-C1-C6alkyl amino, Rg or phenyl; C3-C6cycloalkyl optionally substituted by C1-C6alkyl, N,N-di-C1-C6alkyl amino or C1-C6alkoxy-C1-C6alkyl, and/or two of said optional substituents together with the atoms to which they are bound may form an annulated or spirocyclic 4 - 6 membered saturated heterocyclic ring comprising 1 - 2 O atoms; phenyl optionally substituted by C1-C6alkoxy; a 5 - 6 membered heteroaryl ring having 1 to 3 heteroatoms selected from N and O said ring being optionally substituted by C1-C6alkyl which may be optionally substituted by amino or hydroxy; Rg; or N,N-di-C1-C6alkyl amino carbonyl; and R is phenyl independently substituted two or more times by Ra, 2-pyridyl independently substituted one or more times by Rb, 3-pyridyl independently substituted one or more times by Rc, or 4-pyridyl independently substituted one or more times by Rd; which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.

  本发明描述了新的吡唑基嘧啶衍生物（I）或其药学上可接受的盐；（I）其中，R1是卤素、氰基或由卤素取代的C1-C3烷基；R2是C1-C6烷基，可选地由C1-C6烷基、C2-C6烯基、羟基、N,N-二C1-C6烷基氨基、N-单C1-C6烷基氨基、O-Rg、Rg、苯基或由C1-C6烷氧基取代的C1-C6烷基取代一次或多次，其中该烷氧基再次可选地由C1-C6烷氧基、N,N-二C1-C6烷基氨基、Rg或苯基取代；C3-C6环烷基，可选地由C1-C6烷基、N,N-二C1-C6烷基氨基或C1-C6烷氧基-C1-C6烷基取代，和/或两个可选取代基与它们连接的原子一起可以形成1-2个氧原子的环化或螺环4-6成员饱和杂环环，包括苯基，可选地由C1-C6烷氧基取代；具有1至3个异原子（N和O）的5-6成员杂环环，该环可选地由C1-C6烷基取代，该烷基可选地由氨基或羟基取代；Rg；或N,N-二C1-C6烷基氨基羰基；R独立地由Ra取代两次或两次以上，独立地由Rb取代一次或多次的2-吡啶基，独立地由Rc取代一次或多次的3-吡啶基，或独立地由Rd取代一次或多次的4-吡啶基；这些基本上与MALT1蛋白酶和/或自体蛋白酶活性相互作用，特别是可能抑制该活性。本发明进一步描述了所述新的吡唑基嘧啶衍生物的合成，它们作为药物的用途，特别是通过与MALT1蛋白酶和/或自体蛋白酶活性相互作用。
• FUSED HETEROARYL COMPOUNDS AND THEIR USE AS CAMKII INHIBITORS
  申请人：Cardurion Pharmaceuticals, LLC

  公开号：US20220098207A1

  公开（公告）日：2022-03-31

  The present invention provides a fused heteroaryl compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种具有CaMKII抑制作用的融合杂环芳基化合物，预计可用作心脏疾病（特别是儿茶酚胺多形性室性心动过速、术后房颤、心力衰竭、致命性心律失常）的预防或治疗药物。本发明涉及一种由以下式（I）表示的化合物：其中每个符号如描述中定义，或其药学上可接受的盐。
• Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant
  作者：Ana S. Newton、Maria-Elena Liosi、Sean P. Henry、Luca Deiana、John C. Faver、Stefan G. Krimmer、David E. Puleo、Joseph Schlessinger、William L. Jorgensen

  DOI：10.1016/j.tetlet.2021.153248

  日期：2021.8