2-Hydroxyhexadec-2-enoic acid | 129647-02-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Hydroxyhexadec-2-enoic acid
• 英文别名: 2-hydroxyhexadec-2-enoic acid
• CAS: 129647-02-5
• 化学式: C₁₆H₃₀O₃
• 分子量: 270.41
• InChiKey: HKOQIEFWZHFFQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  19
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Isolation and structural elucidation of the cytostatic linear depsipetide dolastatin 14
  申请人：ARIZONA BOARD OF REGENTS

  公开号：EP0428367A1

  公开（公告）日：1991-05-22

  A new cytostatic depsipeptide, designated "dolastatin 14", was isolated from the Indian Ocean shell-less mollusk Dolabella auricularia. Dolastatin 14 inhibited growth of the PS leukemia with ED₅₀ 0.0018 g/mL. Pharmaceutical preparations and therapeutic regimens utilizing Dolastatin 14, its synthetic counterpart and pharmaceutically active derivatives are disclosed. Dolastatin 14 has the structural formula:

  从印度洋无壳软体动物 Dolabella auricularia 中分离出一种新的细胞抑制性去肽，命名为 "dolastatin 14"。多拉斯汀 14 能抑制 PS 白血病的生长，ED₅₀ 0.0018 克/毫升。本研究公开了利用多拉他汀 14、其合成对应物和药用活性衍生物的药物制剂和治疗方案。多拉他汀 14 的结构式为
• OMEGA-HYDROXYLASE-RELATED FUSION POLYPEPTIDES WITH IMPROVED PROPERTIES
  申请人：REG Life Sciences, LLC

  公开号：EP3087179A1

  公开（公告）日：2016-11-02
• US5138036A
  申请人：——

  公开号：US5138036A

  公开（公告）日：1992-08-11
• [EN] OMEGA-HYDROXYLASE-RELATED FUSION POLYPEPTIDES WITH IMPROVED PROPERTIES<br/>[FR] POLYPEPTIDES DE FUSION ASSOCIÉS À OMÉGA-HYDROXYLASE À PROPRIÉTÉS AMÉLIORÉES
  申请人：REG LIFE SCIENCES LLC

  公开号：WO2015195697A1

  公开（公告）日：2015-12-23

  The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.
• [EN] OMEGA-HYDROXYLASE-RELATED FUSION POLYPEPTIDE VARIANTS WITH IMPROVED PROPERTIES<br/>[FR] VARIANTS DE POLYPEPTIDES DE FUSION LIÉS À OMÉGA-HYDROXYLASE, À PROPRIÉTÉS AMÉLIORÉES
  申请人：REG LIFE SCIENCES LLC

  公开号：WO2017101987A1

  公开（公告）日：2017-06-22

  The disclosure relates to omega-hydroxylase-related fusion polypeptides and variants thereof that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides and variants thereof for the production of omega-hydroxylated fatty acid derivatives.