3-氨基-N-(2-甲基苯)苯甲酰胺 | 14315-20-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-氨基-N-(2-甲基苯)苯甲酰胺
• 中文别名: 3-氨基-N-(2-甲基苯基)苯甲酰胺
• 英文名称: 3-Amino-benz-o-toluidid
• 英文别名: 3-amino-N-(2-methylphenyl)benzamide
• CAS: 14315-20-9
• 化学式: C₁₄H₁₄N₂O
• mdl: MFCD00440152
• 分子量: 226.278
• InChiKey: WMADIBBIIJEEFR-UHFFFAOYSA-N

物化性质

• 熔点：
  143-144 °C(Solv: benzene (71-43-2))
• 沸点：
  333.6±35.0 °C(Predicted)
• 密度：
  1.210±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.071
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)isoxazol-3-yl]-2-methylbenzoyl chloride 、 3-氨基-N-(2-甲基苯)苯甲酰胺 在 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Design, Synthesis, and Insecticidal Activity of Novel Isoxazoline Compounds That Contain Meta-diamides against Fall Armyworm (Spodoptera frugiperda)

  摘要：

  DOI：

  10.1021/acs.jafc.2c07035
• 作为产物：
  描述：

  间硝基苯甲酰氯 在 palladium on activated charcoal 氢气 、 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 反应 15.0h， 生成 3-氨基-N-(2-甲基苯)苯甲酰胺
  参考文献：
  名称：

  Anticonvulsant activity of 2- and 3-aminobenzanilides

  摘要：

  A series of 2- and 3-aminobenzanilides derived from ring-alkylated anilines were prepared and evaluated for anticonvulsant activity. These benzanilides were prepared in the course of studies designed to determine the relationship between the benzamide structure and anticonvulsant effects. The compounds were tested in mice against seizures induced by maximal electroshock (MES) and pentylenetetrazole and in the rotorod assay for neurologic deficit. The 3-aminobenzanilide derived from 2,6-dimethylaniline, 21, was the most potent anti-MES compound, with an ED50 of 13.48 mg/kg and a protective index of 21.11 (PI = TD50/ED50). The activity profile for 21 compares favorably with that for phenobarbital and phenytoin.

  DOI：

  10.1021/jm00158a038

文献信息

• BCL-3 INHIBITORS
  申请人：University College Cardiff Consultants Limited

  公开号：EP3628374A2

  公开（公告）日：2020-04-01

  The present application relates to compounds of any one of Formulae I, Ia, Ib, Ic, Id, Ie, and If. Compounds of Formula I have the structure: wherein A, B, Y, Z, R2, R4, R5, R6, Rq and q are as defined herein. The compounds can be used as inhibitors of Bcl-3 and can be used for the treatment of cancer, particularly metastatic cancer.

  本申请涉及式 I、Ia、Ib、Ic、Id、Ie 和 If 中任何一种的化合物。式 I 的化合物具有如下结构 其中 A、B、Y、Z、R2、R4、R5、R6、Rq 和 q 如本文所定义。这些化合物可用作 Bcl-3 的抑制剂，并可用于治疗癌症，特别是转移性癌症。
• CLARK C. R.; LING CHING-MING; SANSOM R. T., J. MED. CHEM., 29,(1986) N 8, 1534-1537
  作者：CLARK C. R.、 LING CHING-MING、 SANSOM R. T.

  DOI：——

  日期：——
• Anticonvulsant activity of 2- and 3-aminobenzanilides
  作者：C. Randall Clark、Ching Ming Lin、Ricky T. Sansom

  DOI：10.1021/jm00158a038

  日期：1986.8

  A series of 2- and 3-aminobenzanilides derived from ring-alkylated anilines were prepared and evaluated for anticonvulsant activity. These benzanilides were prepared in the course of studies designed to determine the relationship between the benzamide structure and anticonvulsant effects. The compounds were tested in mice against seizures induced by maximal electroshock (MES) and pentylenetetrazole and in the rotorod assay for neurologic deficit. The 3-aminobenzanilide derived from 2,6-dimethylaniline, 21, was the most potent anti-MES compound, with an ED50 of 13.48 mg/kg and a protective index of 21.11 (PI = TD50/ED50). The activity profile for 21 compares favorably with that for phenobarbital and phenytoin.
• Design, Synthesis, and Insecticidal Activity of Novel Isoxazoline Compounds That Contain <i>Meta</i>-diamides against Fall Armyworm (<i>Spodoptera frugiperda</i>)
  作者：Biaobiao Jiang、Di Feng、Fangyi Li、Yuqin Luo、Siqi He、Yawen Dong、Deyu Hu

  DOI：10.1021/acs.jafc.2c07035

  日期：2023.1.18