3-氨基-n-(2,6-二甲基苯基)苯甲酰胺 | 14635-96-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-氨基-n-(2,6-二甲基苯基)苯甲酰胺
• 英文名称: 3-Amino-benz-(2,6-dimethyl-anilid)
• 英文别名: 3-amino-N-(2,6-dimethylphenyl)benzamide
• CAS: 14635-96-2
• 化学式: C₁₅H₁₆N₂O
• mdl: MFCD08691863
• 分子量: 240.305
• InChiKey: LQRZHTFAGDHGGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.133
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为产物：
  描述：

  间硝基苯甲酰氯 在 palladium on activated charcoal 氢气 、 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 反应 15.0h， 生成 3-氨基-n-(2,6-二甲基苯基)苯甲酰胺
  参考文献：
  名称：

  Anticonvulsant activity of 2- and 3-aminobenzanilides

  摘要：

  A series of 2- and 3-aminobenzanilides derived from ring-alkylated anilines were prepared and evaluated for anticonvulsant activity. These benzanilides were prepared in the course of studies designed to determine the relationship between the benzamide structure and anticonvulsant effects. The compounds were tested in mice against seizures induced by maximal electroshock (MES) and pentylenetetrazole and in the rotorod assay for neurologic deficit. The 3-aminobenzanilide derived from 2,6-dimethylaniline, 21, was the most potent anti-MES compound, with an ED50 of 13.48 mg/kg and a protective index of 21.11 (PI = TD50/ED50). The activity profile for 21 compares favorably with that for phenobarbital and phenytoin.

  DOI：

  10.1021/jm00158a038

文献信息

• CLARK C. R.; LING CHING-MING; SANSOM R. T., J. MED. CHEM., 29,(1986) N 8, 1534-1537
  作者：CLARK C. R.、 LING CHING-MING、 SANSOM R. T.

  DOI：——

  日期：——
• 3-and 4-amino-N(alkyl phenyl) benzamide compounds and composition containing same as anticonvulsant drugs
  申请人：Research Corporation Technologies, Inc. (a Delaware corp.)

  公开号：EP0213572B1

  公开（公告）日：1991-07-03
• US4638014A
  申请人：——

  公开号：US4638014A

  公开（公告）日：1987-01-20
• US5064862A
  申请人：——

  公开号：US5064862A

  公开（公告）日：1991-11-12
• Anticonvulsant activity of 2- and 3-aminobenzanilides
  作者：C. Randall Clark、Ching Ming Lin、Ricky T. Sansom

  DOI：10.1021/jm00158a038

  日期：1986.8

  A series of 2- and 3-aminobenzanilides derived from ring-alkylated anilines were prepared and evaluated for anticonvulsant activity. These benzanilides were prepared in the course of studies designed to determine the relationship between the benzamide structure and anticonvulsant effects. The compounds were tested in mice against seizures induced by maximal electroshock (MES) and pentylenetetrazole and in the rotorod assay for neurologic deficit. The 3-aminobenzanilide derived from 2,6-dimethylaniline, 21, was the most potent anti-MES compound, with an ED50 of 13.48 mg/kg and a protective index of 21.11 (PI = TD50/ED50). The activity profile for 21 compares favorably with that for phenobarbital and phenytoin.