2-[(1R,4R,8R,10S,16S,34S)-34-[(2S)-butan-2-yl]-8,22-dihydroxy-13-[(2R,3R)-3-hydroxybutan-2-yl]-2,5,11,14,27,30,33,36,39-nonaoxo-27lambda4-thia-3,6,12,15,25,29,32,35,38-nonazapentacyclo[14.12.11.06,10.018,26.019,24]nonatriaconta-18(26),19(24),20,22-tetraen-4-yl]acetamide | 21150-23-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[(1R,4R,8R,10S,16S,34S)-34-[(2S)-butan-2-yl]-8,22-dihydroxy-13-[(2R,3R)-3-hydroxybutan-2-yl]-2,5,11,14,27,30,33,36,39-nonaoxo-27lambda4-thia-3,6,12,15,25,29,32,35,38-nonazapentacyclo[14.12.11.06,10.018,26.019,24]nonatriaconta-18(26),19(24),20,22-tetraen-4-yl]acetamide
• 英文别名: 2-[(1R,4R,8R,10S,16S,34S)-34-[(2S)-butan-2-yl]-8,22-dihydroxy-13-[(2R,3R)-3-hydroxybutan-2-yl]-2,5,11,14,27,30,33,36,39-nonaoxo-27λ4-thia-3,6,12,15,25,29,32,35,38-nonazapentacyclo[14.12.11.06,10.018,26.019,24]nonatriaconta-18(26),19(24),20,22-tetraen-4-yl]acetamide
• CAS: 21150-23-2；13567-11-8
• 化学式: C₃₉H₅₄N₁₀O₁₃S
• 分子量: 903.0
• InChiKey: WVHGJJRMKGDTEC-DYTWYUBMSA-N

物化性质

• 沸点：
  1505.8±65.0 °C(Predicted)
• 密度：
  1.1427 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.4
• 重原子数：
  63
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  380
• 氢给体数：
  12
• 氢受体数：
  14

ADMET

毒理性

• 相互作用

药物成分.../已经/有报告称可以保护小鼠免受剧毒剂量的鹅膏毒肽和毒伞素/包括毒伞菌素/的侵害。这个清单包括高剂量的青霉素、氯霉素、非那西丁以及许多其他成分...这些解毒剂都没有经过充分临床试验，因此目前不能推荐使用。/毒伞菌素/

...PHARMACOLOGICAL AGENTS.../HAVE/ BEEN REPORTED TO PROTECT MICE AGAINST LETHAL DOSES OF PHALLOTOXINS & AMATOXINS /INCLUDING THE AMANITINS/. THE LIST INCLUDES HIGH DOSES OF PENICILLIN, CHLORAMPHENICOL, PHENYLBUTAZONE, & MANY OTHERS... NONE OF THESE ANTIDOTES HAS RECEIVED AN ADEQUATE CLINICAL TRIAL & SO NONE CAN BE RECOMMENDED TODAY. /AMANITINS/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

高度有毒。会导致流涎、呕吐、血便、发绀、肌肉抽搐、惊厥。可能致命。/鹅膏蕈氨酸/

HIGHLY TOXIC. CAUSES SALIVATION, VOMITING, BLOODY STOOLS, CYANOSIS, MUSCULAR TWITCHING, CONVULSIONS. CAN BE FATAL. /AMANITIN/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

抑制/ RNA 聚合酶 II .../干扰/ 信使 RNA 的合成。这些毒素破坏了肝细胞膜和内质网的结构。amanitin 也是一种直接作用于肾脏的毒素，会导致肾小管坏死。/amanitins/

.../INHIBITS/ RNA POLYMERASE II &.../INTERFERES/ WITH THE SYNTHESIS OF MRNA. THE TOXINS DISRUPT HEPATIC CELL MEMBRANES & THE STRUCTURE OF THE ENDOPLASMIC RETICULUM. AMANITIN IS ALSO A DIRECTLY ACTING NEPHROTOXIN & CAUSES TUBULAR NECROSIS. /AMANITINS/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

症状出现缓慢，通常在摄入后6到24小时出现；包括腹痛、血尿和腹泻。死亡通常是由于肝或肾功能衰竭。/鹅膏毒肽/

SYMPTOMS ARE SLOW IN ONSET, APPEARING 6 TO 24 HR AFTER INGESTION; THEY INCLUDE ABDOMINAL PAIN, HEMATURIA, & DIARRHEA. DEATH USUALLY RESULTS FROM HEPATIC OR RENAL FAILURE. /AMANITINS/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

肝脏损伤通常是人类的重大病变。似乎胆汁流动迅速停止，肝脏糖原减少，出现低血糖，有时伴有初期的高血糖，肝细胞核RNA含量下降，以及肝细胞蛋白质合成失败，但尚未确定这些效应中是否有任何一个是最初的病变。/鹅膏蕈碱/

...LIVER INJURY IS USUALLY THE MAJOR LESION IN MAN. THERE APPEARS TO BE A PROMPT CESSATION OF BILE FLOW, A REDUCTION IN LIVER GLYCOGEN, HYPOGLYCEMIA WITH OR WITHOUT AN INITIAL PHASE OF HYPERGLYCEMIA, A FALL IN THE RNA CONTENT OF LIVER NUCLEI, & A FAILURE OF LIVER CELL PROTEIN SYNTHESIS, BUT WHETHER OR NOT ANY OF THESE EFFECTS IS THE PRIMARY LESION HAS NOT BEEN ESTABLISHED. /AMANITINS/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  6.1(a)

制备方法与用途

类别：有毒物品

• 毒性分级：剧毒
• 急性毒性：腹腔-小鼠 LD50: 0.2 毫克/公斤
• 可燃性危险特性：可燃；燃烧产生有毒的氮氧化物和硫氧化物烟雾
• 储运特性：库房需通风、低温干燥

灭火剂：

• 干粉
• 泡沫
• 砂土
• 二氧化碳
• 雾状水