N-Me-L-homotyrosine | 1108702-36-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Me-L-homotyrosine
• 英文别名: Methylhomotyrosine；(2S)-4-(4-hydroxyphenyl)-2-(methylamino)butanoic acid
• CAS: 1108702-36-8
• 化学式: C₁₁H₁₅NO₃
• 分子量: 209.245
• InChiKey: FAHSGEKVKNNPKL-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-Me-L-homotyrosine methyl ester 在 lithium iodide 、 水 作用下， 以 乙酸乙酯 为溶剂， 反应 20.0h， 生成 N-Me-L-homotyrosine
  参考文献：
  名称：

  Homotyrosine-Containing Cyanopeptolins 880 and 960 and Anabaenopeptins 908 and 915 from Planktothrix agardhii CYA 126/8

  摘要：

  Two homotyrosine-bearing cyanopeptolins are described from Planktothrix agardhii CYA 126/8. The compounds feature a common homotyrosine-containing cyclohexadepsipeptide and differ by sulfation of an exocyclically located 2-O-methyl-D-glyceric acid residue. In addition we describe two anabaenopeptins, which contain two homotyrosine residues, one of which is N-methylated. The anabaenopeptins have a common cyclopentapeptide portion and differ in the amino acid linked to it via an ureido bond, arginine and tyrosine, respectively.

  DOI：

  10.1021/np800557m

文献信息

• [EN] A CHEMICALLY AND METABOLICALLY STABLE DIPEPTIDE POSSESSING POTENT SODIUM CHANNEL BLOCKER ACTIVITY<br/>[FR] DIPEPTIDE STABLE D'UN POINT DE VUE CHIMIQUE ET MÉTABOLIQUE CARACTÉRISÉ PAR UNE PUISSANTE ACTIVITÉ INHIBITRICE SUR LES CANAUX SODIQUES
  申请人：JOHNSON MICHAEL ROSS

  公开号：WO2013003444A1

  公开（公告）日：2013-01-03

  A very stable, selective and renally safe sodium channel blocker represented by the formula: The invention also includes a variety of compositions, combinations and methods of treatment usin this inventive sodium channel blocker.

  一种非常稳定、选择性高且肾脏安全的钠通道阻滞剂，其化学式为：本发明还包括多种组合和治疗方法，使用这种创新的钠通道阻滞剂。
• Homotyrosine-Containing Cyanopeptolins 880 and 960 and Anabaenopeptins 908 and 915 from <i>Planktothrix agardhii</i> CYA 126/8
  作者：Hilary S. Okumura、Benjamin Philmus、Cyril Portmann、Thomas K. Hemscheidt

  DOI：10.1021/np800557m

  日期：2009.1.23

  Two homotyrosine-bearing cyanopeptolins are described from Planktothrix agardhii CYA 126/8. The compounds feature a common homotyrosine-containing cyclohexadepsipeptide and differ by sulfation of an exocyclically located 2-O-methyl-D-glyceric acid residue. In addition we describe two anabaenopeptins, which contain two homotyrosine residues, one of which is N-methylated. The anabaenopeptins have a common cyclopentapeptide portion and differ in the amino acid linked to it via an ureido bond, arginine and tyrosine, respectively.