3-氯-4-甲基-6-(噻吩-2-基)哒嗪 | 32176-55-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 3-氯-4-甲基-6-(噻吩-2-基)哒嗪
• 英文名称: 3-chloro-4-methyl-6-(thien-2-yl)pyridazine
• 英文别名: 3-chloro-4-methyl-6-(2-thienyl)pyridazine；3-chloro-4-methyl-6-thiophen-2-ylpyridazine
• CAS: 32176-55-9
• 化学式: C₉H₇ClN₂S
• 分子量: 210.687
• InChiKey: VPNGLLJBAXZKOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-氯-4-甲基-6-(噻吩-2-基)哒嗪 、 肼 以50%的产率得到
  参考文献：
  名称：

  NADA, A. A.;HAGGAG, B.;ABDEL-HALIM, S.;RIFAE, Z. M., EGYPT. J. CHEM., 1983, 26, N 5, 371-377

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲基-6-(2-噻吩基)哒嗪-3-酮 在 三氯氧磷 作用下， 生成 3-氯-4-甲基-6-(噻吩-2-基)哒嗪
  参考文献：
  名称：

  3-Aminopyridazine derivatives with atypical antidepressant, serotonergic and dopaminergic activities

  摘要：

  Minaprine [3-[(beta-morpholinoethyl)amino]-4-methyl-6-phenylpyridazine dihydrochloride] is active in most animal models of depression and exhibits in vivo a dual dopaminomimetic and serotoninomimetic activity profile. In an attempt to dissociate these two effects and to characterize the responsible structural requirements, a series of 47 diversely substituted analogues of minaprine were synthesized and tested for their potential antidepressant, serotonergic, and dopaminergic activities. The structure-activity relationships show that dopaminergic and serotonergic activities can be dissociated. Serotonergic activity appears to be correlated mainly with the substituent in the 4-position of the pyridazine ring whereas the dopaminergic activity appears to be dependent on the presence, or in the formation, of a para-hydroxylated aryl ring in the 6-position of the pyridazine ring.

  DOI：

  10.1021/jm00123a004

文献信息

• Herbicidal pyridazines and method for controlling undesirable plant
  申请人：American Cyanamid Company

  公开号：US04623376A1

  公开（公告）日：1986-11-18

  This invention relates to a method for controlling undesirable monocotyledonous and dicotyledonous plant species by applying to the foliage thereof or to soil containing seeds or other propagating organs of said plant species, a herbicidally-effective amount of a pyridazine compound. The invention also relates to novel herbicidally-effective pyridazine compounds.

  本发明涉及一种控制不良单子叶和双子叶植物物种的方法，通过向其叶面或含有该植物物种种子或其他繁殖器官的土壤中施加具有除草作用的吡嗪化合物的有效量。本发明还涉及新的具有除草作用的吡嗪化合物。
• WERMUTH, CAMILLE-GEORGES;SCHLEWER, GILBERT;BOURGUIGNON, JEAN-JACQUES;MAGH+, J. MED. CHEM., 32,(1989) N, C. 528-537
  作者：WERMUTH, CAMILLE-GEORGES、SCHLEWER, GILBERT、BOURGUIGNON, JEAN-JACQUES、MAGH+

  DOI：——

  日期：——
• KAN, J. P.;BIZIERE, K.;WERMUTH, C. -G.
  作者：KAN, J. P.、BIZIERE, K.、WERMUTH, C. -G.

  DOI：——

  日期：——
• US4524070A
  申请人：——

  公开号：US4524070A

  公开（公告）日：1985-06-18
• US4623376A
  申请人：——

  公开号：US4623376A

  公开（公告）日：1986-11-18