methyl 3-(5-methoxy-3-pyridyl)benzoate | 1373232-69-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: methyl 3-(5-methoxy-3-pyridyl)benzoate
• 英文别名: Methyl 3-(5-methoxypyridin-3-yl)benzoate
• CAS: 1373232-69-9
• 化学式: C₁₄H₁₃NO₃
• 分子量: 243.262
• InChiKey: CQXFMTADGDSFSW-UHFFFAOYSA-N

物化性质

• 沸点：
  396.9±32.0 °C(Predicted)
• 密度：
  1.159±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  48.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 3-(5-methoxy-3-pyridyl)benzoate 在 lithium hydroxide monohydrate 、 水 作用下， 以 四氢呋喃 为溶剂， 以52 %的产率得到3-(5-methoxy-3-pyridyl)benzoic acid
  参考文献：
  名称：

  [EN] PROTEIN DEGRADERS AND USES THEREOF
  [FR] AGENTS DE DÉGRADATION DE PROTÉINES ET LEURS UTILISATIONS

  摘要：

  The present invention relates to novel bifunctional compounds, as well as compositions thereof, which modulate KLHDC2 and/or function to recruit targeted proteins to KLHDC2 for degradation. These bifunctional compounds, which find utility as modulators of targeted ubiquitination of a variety of polypeptides and other proteins, are then degraded and/or otherwise inhibited by the bifunctional compounds. In addition, methods of using an effective amount of the inventive compounds are disclosed for the treatment or amelioration of a disease condition, such as cancer.

  公开号：

  WO2023192578A1
• 作为产物：
  描述：

  3-甲氧羰基苯硼酸频哪醇酯 、 3-溴-5-甲氧基吡啶 在 四(三苯基膦)钯 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以90 %的产率得到methyl 3-(5-methoxy-3-pyridyl)benzoate
  参考文献：
  名称：

  [EN] PROTEIN DEGRADERS AND USES THEREOF
  [FR] AGENTS DE DÉGRADATION DE PROTÉINES ET LEURS UTILISATIONS

  摘要：

  The present invention relates to novel bifunctional compounds, as well as compositions thereof, which modulate KLHDC2 and/or function to recruit targeted proteins to KLHDC2 for degradation. These bifunctional compounds, which find utility as modulators of targeted ubiquitination of a variety of polypeptides and other proteins, are then degraded and/or otherwise inhibited by the bifunctional compounds. In addition, methods of using an effective amount of the inventive compounds are disclosed for the treatment or amelioration of a disease condition, such as cancer.

  公开号：

  WO2023192578A1