2-(2-furyl)-4-(N-tosyl-L-alanyloxy)thiazol | 285995-87-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(2-furyl)-4-(N-tosyl-L-alanyloxy)thiazol
• 英文别名: 2-(furan-2-yl)-4-(N-tosyl-L-alanyloxy)thiazol；[2-(furan-2-yl)-1,3-thiazol-4-yl] (2S)-2-[(4-methylphenyl)sulfonylamino]propanoate
• CAS: 285995-87-1
• 化学式: C₁₇H₁₆N₂O₅S₂
• 分子量: 392.456
• InChiKey: HCTDUVGQUZALDO-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  135
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Composition and device for detecting leukocytes in urine
  申请人：Hypoguard America Limited

  公开号：US20020058301A1

  公开（公告）日：2002-05-16

  Thiazole esters are suitable for detecting the presence of leukocytes in urine. Such thiazole esters are suitable for use in compositions, diagnostic devices, and methods for detecting the presence of leukocytes. In one embodiment, a thiazole ester is of the formula: 1 or a salt or solvated salt thereof, in which A is an N-blocked amino acid residue or an N-blocked peptide chain, preferably N-blocked alanine or N-blocked polyalanine; and R 1 is unsubstituted or substituted heteroaryl; alkenyl substituted with unsubstituted or substituted aryl; or alkenyl substituted with unsubstituted or substituted heteroaryl. For example, R 1 may be thienyl, pyridyl, furyl, styryl, pyrrolyl, or indolyl. In still another embodiment, the thiazole ester includes unsubstituted or substituted fused hydrocarbyl rings as a substituent. In one embodiment, fused hydrocarbyl rings include naphthyl. In another embodiment, fused hydrocarbyl rings include anthryl.

  噻唑酯适用于检测尿液中白细胞的存在。这种噻唑酯适用于用于检测白细胞的组成物、诊断设备和方法。在一种实施例中，噻唑酯的公式为：1，或其盐或溶剂化盐，其中A是N-保护的氨基酸残基或N-保护的肽链，优选的是N-保护的丙氨酸或N-保护的多丙氨酸；而R1为未取代或取代的杂环芳基；取代为未取代或取代的芳基的烯基；或取代为未取代或取代的杂环芳基的烯基。例如，R1可以是噻吩基、吡啶基、呋喃基、苯乙烯基、吡咯基或吲哚基。在另一种实施例中，噻唑酯包括未取代或取代的融合烃环作为取代基。在一种实施例中，融合烃环包括萘基。在另一种实施例中，融合烃环包括蒽基。
• COMPOSITION AND DEVICE FOR DETECTING LEUKOCYTES IN URINE
  申请人：Hypoguard America Limited

  公开号：EP1163360A2

  公开（公告）日：2001-12-19
• US6348324B1
  申请人：——

  公开号：US6348324B1

  公开（公告）日：2002-02-19
• US6503725B2
  申请人：——

  公开号：US6503725B2

  公开（公告）日：2003-01-07
• [EN] COMPOSITION AND DEVICE FOR DETECTING LEUKOCYTES IN URINE<br/>[FR] COMPOSITION ET DISPOSITIF DE DETECTION DE LEUCOCYTES DANS L'URINE
  申请人：CHRONIMED INC

  公开号：WO2000043535A2

  公开（公告）日：2000-07-27

  Thiazole esters are suitable for detecting the presence of leukocytes in urine. Such thiazole esters are suitable for use in compositions, diagnostic devices, and methods for detecting the presence of leukocytes. In one embodiment, a thiazole ester is of formula (I) or a salt or solvated salt thereof, in which A is an N-blocked amino acid residue or an N-blocked peptide chain, preferably N-blocked alanine or N-blocked polyalanine; and R1 is unsubstituted or substituted heteroaryl; alkenyl substituted with unsubstituted or substituted aryl; or alkenyl substituted with unsubstituted or substituted heteroaryl. For example, R1 may be thienyl, pyridyl, furyl, styryl, pyrrolyl, or indolyl. In still another embodiment, the thiazole ester includes unsubstituted or substituted fused hydrocarbyl rings as a substituent. In one embodiment, fused hydrocarbyl rings include naphthyl. In another embodiment, fused hydrocarbyl rings include anthryl.