Ethyl (E)-3-[1-[2-(4-Methoxybenzylamino)-4-pyrimidinyl]-5-methyl-4-pyrazolyl]-2-propenoate | 210992-73-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Ethyl (E)-3-[1-[2-(4-Methoxybenzylamino)-4-pyrimidinyl]-5-methyl-4-pyrazolyl]-2-propenoate
• 英文别名: ethyl (E)-3-[1-[2-[(4-methoxyphenyl)methylamino]pyrimidin-4-yl]-5-methylpyrazol-4-yl]prop-2-enoate
• CAS: 210992-73-7
• 化学式: C₂₁H₂₃N₅O₃
• 分子量: 393.445
• InChiKey: YBYOVQYNYIIUMI-JXMROGBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  91.2
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Ethyl (E)-3-[1-[2-(4-Methoxybenzylamino)-4-pyrimidinyl]-5-methyl-4-pyrazolyl]-2-propenoate 在 二异丁基氢化铝 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 (E)-3-{1-[2-(4-Methoxy-benzylamino)-pyrimidin-4-yl]-5-methyl-1H-pyrazol-4-yl}-prop-2-en-1-ol
  参考文献：
  名称：

  Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity

  摘要：

  Pyrimidinyl pyrazole derivatives 1-4, prepared as a new scaffold of an anti-tumor agent, showed antiproliferative activity against human lung cancer cell lines and inhibited tubulin polymerization. Furthermore, it was found that compound 2 bound at the colchicine site on tubulin, but the tubulin binding pattern was different from that of colchicine. Here, we describe the synthesis of the derivatives and the differences of the action mechanism on tubulin polymerization inhibition between compound 2 and colchicine. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00568-1
• 作为产物：
  描述：

  2-(4-Methoxy-benzylamino)-pyrimidin-4-ol 在 manganese(IV) oxide 、 二异丁基氢化铝 、 potassium carbonate 、 肼 、 三氯氧磷 作用下， 以 1,4-二氧六环 、 乙醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 73.0h， 生成 Ethyl (E)-3-[1-[2-(4-Methoxybenzylamino)-4-pyrimidinyl]-5-methyl-4-pyrazolyl]-2-propenoate
  参考文献：
  名称：

  Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity

  摘要：

  Pyrimidinyl pyrazole derivatives 1-4, prepared as a new scaffold of an anti-tumor agent, showed antiproliferative activity against human lung cancer cell lines and inhibited tubulin polymerization. Furthermore, it was found that compound 2 bound at the colchicine site on tubulin, but the tubulin binding pattern was different from that of colchicine. Here, we describe the synthesis of the derivatives and the differences of the action mechanism on tubulin polymerization inhibition between compound 2 and colchicine. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00568-1

文献信息

• Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity
  作者：Hitoshi Ohki、Kenji Hirotani、Hiroyuki Naito、Satoru Ohsuki、Megumi Minami、Akio Ejima、Yukiko Koiso、Yuichi Hashimoto

  DOI：10.1016/s0960-894x(02)00568-1

  日期：2002.11

  Pyrimidinyl pyrazole derivatives 1-4, prepared as a new scaffold of an anti-tumor agent, showed antiproliferative activity against human lung cancer cell lines and inhibited tubulin polymerization. Furthermore, it was found that compound 2 bound at the colchicine site on tubulin, but the tubulin binding pattern was different from that of colchicine. Here, we describe the synthesis of the derivatives and the differences of the action mechanism on tubulin polymerization inhibition between compound 2 and colchicine. (C) 2002 Elsevier Science Ltd. All rights reserved.