3,5-Bis-[2-(3,4,5-tris-benzyloxy-benzoylamino)-ethoxy]-benzoic acid | 461659-15-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-Bis-[2-(3,4,5-tris-benzyloxy-benzoylamino)-ethoxy]-benzoic acid
• CAS: 461659-15-4
• 化学式: C₆₇H₆₀N₂O₁₂
• 分子量: 1085.22
• InChiKey: GTFMRDAKDFEBFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.48
• 重原子数：
  81.0
• 可旋转键数：
  29.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  169.34
• 氢给体数：
  3.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  3,5-Bis-[2-(3,4,5-tris-benzyloxy-benzoylamino)-ethoxy]-benzoic acid 在 palladium on activated charcoal 氢气 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以100%的产率得到3,5-Bis[2-[(3,4,5-trihydroxybenzoyl)amino]ethoxy]benzoic acid
  参考文献：
  名称：

  Synthesis and biological activity of polygalloyl-dendrimers as stable tannic acid mimics

  摘要：

  Inspired by the structure of tannic acid, first- to third-generation dendrimers containing two, four, and eight galloyl moieties were synthesized. Stability, antioxidant activity and collagen cross-linking activity of the natural product and its dendrimer analogues were compared. The experimental results indicate that polygalloyl dendrimers might be used as new lead compounds to improve the long-term healing characteristics of burn wounds. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00245-7
• 作为产物：
  描述：

  3,4,5-三苄氧基苯甲酸 在 sodium hydroxide 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 1,4-二氧六环 、 甲醇 、 二氯甲烷 为溶剂， 生成 3,5-Bis-[2-(3,4,5-tris-benzyloxy-benzoylamino)-ethoxy]-benzoic acid
  参考文献：
  名称：

  Synthesis and biological activity of polygalloyl-dendrimers as stable tannic acid mimics

  摘要：

  Inspired by the structure of tannic acid, first- to third-generation dendrimers containing two, four, and eight galloyl moieties were synthesized. Stability, antioxidant activity and collagen cross-linking activity of the natural product and its dendrimer analogues were compared. The experimental results indicate that polygalloyl dendrimers might be used as new lead compounds to improve the long-term healing characteristics of burn wounds. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00245-7