(2S,5S)-5-Acetylthio-2-dimethylcarbamoyl-1-p-nitrobenzyloxycarbonylpiperidine | 133825-28-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,5S)-5-Acetylthio-2-dimethylcarbamoyl-1-p-nitrobenzyloxycarbonylpiperidine
• 英文别名: (4-nitrophenyl)methyl (2S,5S)-5-acetylsulfanyl-2-(dimethylcarbamoyl)piperidine-1-carboxylate
• CAS: 133825-28-2
• 化学式: C₁₈H₂₃N₃O₆S
• 分子量: 409.463
• InChiKey: RDZRRLCPLDFAFV-HOTGVXAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  138
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Piperidylthiocarbapenem derivatives
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0411636A2

  公开（公告）日：1991-02-06

  A compound represented by the general formula (I): wherein R¹ is a hydrogen atom or a methyl group; R² and R³, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, or taken together with the adjacent nitrogen atom, jointly represent a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group, a piperidino group, a piperazinyl group, a 4-lower alkylpiperazinyl group, a morpholino group and a thiomorpholino group; and A is a single bond, a lower alkylene group, a lower alkenylene group or a lower alkynylene group; or a pharmaceutically acceptable salt or ester thereof. The compound of the general formula (I) and their salts or esters exhibit excellent antibacterial activity.

  由通式(I)代表的化合物： 其中 R¹是氢原子或甲基；R²和 R³可以相同或不同，各自代表氢原子或低级烷基，或与相邻的氮原子一起共同代表选自氮丙啶基、氮杂环丁基、吡咯烷基、哌啶基、哌嗪基、4-低级烷基哌嗪基、吗啉基和硫代吗啉基组成的杂环基团；和 A 是单键、低级烯基、低级炔基或低级炔基；或其药学上可接受的盐或酯。 通式（I）的化合物及其盐或酯具有优异的抗菌活性。
• US5153188A
  申请人：——

  公开号：US5153188A

  公开（公告）日：1992-10-06