2,2-Difluoro-2-(2-methylphenyl)ethan-1-ol | 1365808-64-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2-Difluoro-2-(2-methylphenyl)ethan-1-ol
• 英文别名: 2,2-difluoro-2-(2-methylphenyl)ethanol
• CAS: 1365808-64-5
• 化学式: C₉H₁₀F₂O
• 分子量: 172.175
• InChiKey: ZGGDLMNHVCFOOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,2-二氟-(2-甲基苯基)乙酸乙酯 在 Ru-MACHO 、 氢气 、 sodium methylate 作用下， 以 甲醇 为溶剂， 38.0 ℃ 、1.0 MPa 条件下， 生成 2,2-Difluoro-2-(2-methylphenyl)ethan-1-ol
  参考文献：
  名称：

  METHOD FOR PRODUCING BETA-FLUOROALCOHOL

  摘要：

  公开号：

  EP2650276B1

文献信息

• METHOD FOR PRODUCING -FLUOROALCOHOL
  申请人：Central Glass Company, Limited

  公开号：EP2650276A1

  公开（公告）日：2013-10-16

  A production method of a β-fluoroalcohol includes performing a reaction of an α-fluoroester with hydrogen gas (H2) in the presence of a specific ruthenium complex (i.e. a ruthenium complex of the general formula [2], preferably a ruthenium complex of the general formula [4]). This production method can employ a suitable hydrogen pressure of 1 MPa or less by the use of such a specific ruthenium complex and does not require a high-pressure gas production facility when put in industrial practice. In addition, this production method can remarkably reduce the amount of catalyst used therein (to e.g. a substrate/catalyst ratio of 20,000) in comparison to the substrate/catalyst ratio conventional reduction of α-fluoroalcohol. It is possible by these reduction in hydrogen pressure and catalyst amount to largely reduce the production cost of the β-fluoroalcohol.

  一种β-氟醇的生产方法包括在特定的钌络合物（即通式[2]的钌络合物，最好是通式[4]的钌络合物）存在下，使α-氟酯与氢气（H2）反应。通过使用这种特定的钌络合物，这种生产方法可以使用 1 兆帕或更小的合适氢气压力，并且在工业实践中不需要高压气体生产设备。此外，与传统的α-氟醇还原的底物/催化剂比相比，这种生产方法可以显著减少催化剂的用量（例如，底物/催化剂比为 20,000）。通过降低氢气压力和催化剂用量，可以在很大程度上降低 β-氟乙醇的生产成本。
• Method For Producing Beta-Fluoroalcohol
  申请人：Ishii Akihiro

  公开号：US20130303774A1

  公开（公告）日：2013-11-14

  A production method of a β-fluoroalcohol includes performing a reaction of an α-fluoroester with hydrogen gas (H 2 ) in the presence of a specific ruthenium complex (i.e. a ruthenium complex of the general formula [2], preferably a ruthenium complex of the general formula [4]). This production method can employ a suitable hydrogen pressure of 1 MPa or less by the use of such a specific ruthenium complex and does not require a high-pressure gas production facility when put in industrial practice. In addition, this production method can remarkably reduce the amount of catalyst used therein (to e.g. a substrate/catalyst ratio of 20,000) in comparison to the substrate/catalyst ratio conventional reduction of α-fluoroalcohol. It is possible by these reduction in hydrogen pressure and catalyst amount to largely reduce the production cost of the β-fluoroalcohol.
• US8658840B2
  申请人：——

  公开号：US8658840B2

  公开（公告）日：2014-02-25