2-[4-(5-butoxy-4-ethyl-6-methoxy-8-quinolylamino)pentyl]-1,3-isoindolinedione | 663953-29-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-[4-(5-butoxy-4-ethyl-6-methoxy-8-quinolylamino)pentyl]-1,3-isoindolinedione
• CAS: 663953-29-5
• 化学式: C₂₉H₃₅N₃O₄
• 分子量: 489.615
• InChiKey: OQMIGSTUVHTSLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.86
• 重原子数：
  36.0
• 可旋转键数：
  12.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  80.76
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  2-[4-(5-butoxy-4-ethyl-6-methoxy-8-quinolylamino)pentyl]-1,3-isoindolinedione 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 8.0h， 以84%的产率得到4-N-(5-butoxy-4-ethyl-6-methoxyquinolin-8-yl)pentane-1,4-diamine
  参考文献：
  名称：

  8-Quinolinamines and Their pro prodrug conjugates as potent blood-Schizontocidal antimalarial agents

  摘要：

  Synthesis and antimalarial activities of N-8-(4-amino-1-methylbutyl)-5-alkoxy-4-ethyl-6-methoxy-8-quinolinamines (5) and their pro prodrug analogues (6-7) prepared by covalently linking 5 to the redox-sensitive (8) and esterase-sensitive (9) linkers through the amide linkage are reported. The most effective 8-quinolinamines [5c (R = C5H11) and 5f (R = C8H17)] A have exhibited in vitro and in vivo biological efficacy superior to that of the standard drug chloroquine against both drug-sensitive and drug-resistant malaria strains. Analogues 6-7 were evaluated for in vivo blood-schizontocidal activity as potential pro prodrug models for the primary amino group containing 8-quinolinamines (5). The most effective pro prodrug analogue (6c) has displayed promising activities against drug-sensitive and drug-resistant strains of Plasmodia in vivo. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.07.003
• 作为产物：
  描述：

  在 Raney nickel (T₁ grade) arsenic(V) oxide 、 磷酸 、 氢气 、 三乙胺 作用下， 以 乙醇 为溶剂， 80.0~120.0 ℃ 、310.26 kPa 条件下， 反应 27.75h， 生成 2-[4-(5-butoxy-4-ethyl-6-methoxy-8-quinolylamino)pentyl]-1,3-isoindolinedione
  参考文献：
  名称：

  8-Quinolinamines and Their pro prodrug conjugates as potent blood-Schizontocidal antimalarial agents

  摘要：

  Synthesis and antimalarial activities of N-8-(4-amino-1-methylbutyl)-5-alkoxy-4-ethyl-6-methoxy-8-quinolinamines (5) and their pro prodrug analogues (6-7) prepared by covalently linking 5 to the redox-sensitive (8) and esterase-sensitive (9) linkers through the amide linkage are reported. The most effective 8-quinolinamines [5c (R = C5H11) and 5f (R = C8H17)] A have exhibited in vitro and in vivo biological efficacy superior to that of the standard drug chloroquine against both drug-sensitive and drug-resistant malaria strains. Analogues 6-7 were evaluated for in vivo blood-schizontocidal activity as potential pro prodrug models for the primary amino group containing 8-quinolinamines (5). The most effective pro prodrug analogue (6c) has displayed promising activities against drug-sensitive and drug-resistant strains of Plasmodia in vivo. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.07.003