(4S)-4-[(pyridin-2-yl)methyl]azetidin-2-one | 250135-83-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (4S)-4-[(pyridin-2-yl)methyl]azetidin-2-one
• 英文别名: (4S)-4-(pyridin-2-ylmethyl)azetidin-2-one
• CAS: 250135-83-2
• 化学式: C₉H₁₀N₂O
• 分子量: 162.191
• InChiKey: DBLQRQYYJIVZPN-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-Methyl-N-{{4-(trifluoromethyl)phenyl}methyl}carbamoyl chloride 、 (4S)-4-[(pyridin-2-yl)methyl]azetidin-2-one 在 双(三甲基硅烷基)氨基钾 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 以61%的产率得到(4S)-N-methyl-2-oxo-4-(pyridin-2-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]azetidine-1-carboxamide
  参考文献：
  名称：

  Synthesis and antiviral activity of monobactams inhibiting the human cytomegalovirus protease

  摘要：

  A series of monobactam inhibitors of HCMV (N-o) protease bearing a heterocycle linked by a methylene group at C-4 is described. Inhibitors containing a heterocycle such as a 2-furyl, 2-thiophenyl, 4-methyl-2-tetrazole and 2-benzothiazole were found to be active in a plaque reduction assay. Furthermore, 2-benzothiazole derivatives were shown to inhibit the HCMV protease activity inside cells by using a cell transfection assay, indicating that their antiviral activity in the plaque reduction assay could be attributed to protease inhibition. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(99)00094-2
• 作为产物：
  描述：

  (4R)-4-[hydroxy(pyridin-2-yl)methyl]-1-(triisopropylsilanyl)azetidin-2-one 在 4-二甲氨基吡啶 、 偶氮二异丁腈 、 三苯基氢化锡 、 cesium fluoride 作用下， 以 甲醇 、 二氯甲烷 、 苯 为溶剂， 反应 1.0h， 生成 (4S)-4-[(pyridin-2-yl)methyl]azetidin-2-one
  参考文献：
  名称：

  Synthesis and antiviral activity of monobactams inhibiting the human cytomegalovirus protease

  摘要：

  A series of monobactam inhibitors of HCMV (N-o) protease bearing a heterocycle linked by a methylene group at C-4 is described. Inhibitors containing a heterocycle such as a 2-furyl, 2-thiophenyl, 4-methyl-2-tetrazole and 2-benzothiazole were found to be active in a plaque reduction assay. Furthermore, 2-benzothiazole derivatives were shown to inhibit the HCMV protease activity inside cells by using a cell transfection assay, indicating that their antiviral activity in the plaque reduction assay could be attributed to protease inhibition. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(99)00094-2