(3R,3aS,6S,6aS,8S,9R,9aR,9br)-8-[(4-methoxybenzyl)oxy]-3,6,9-trimethyl-6a,7,8,9,9a,9bhexahydro-6H-3a,6-epidioxyazuleno[4,5-b]furan-2(3H)-one | 1254986-26-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3R,3aS,6S,6aS,8S,9R,9aR,9br)-8-[(4-methoxybenzyl)oxy]-3,6,9-trimethyl-6a,7,8,9,9a,9bhexahydro-6H-3a,6-epidioxyazuleno[4,5-b]furan-2(3H)-one
• 英文别名: thaperoxide；(1S,2R,5R,6R,7R,8S,10S,11S)-8-[(4-methoxyphenyl)methoxy]-2,7,11-trimethyl-4,12,13-trioxatetracyclo[9.2.2.01,5.06,10]pentadec-14-en-3-one
• CAS: 1254986-26-9
• 化学式: C₂₃H₂₈O₆
• 分子量: 400.472
• InChiKey: NODRVSYGMRVKQK-FYQPDDGJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (3R,3aS,6S,6aS,8S,9R,9aR,9br)-8-[(4-methoxybenzyl)oxy]-3,6,9-trimethyl-6a,7,8,9,9a,9bhexahydro-6H-3a,6-epidioxyazuleno[4,5-b]furan-2(3H)-one 在 二异丁基氢化铝 、 水 、 Rochelle's salt 作用下， 以 二氯甲烷 为溶剂， 反应 1.17h， 以94%的产率得到(3R,3aS,6S,6aS,8S,9R,9aR,9bR)-8-[(4-methoxybenzyl)oxy]-3,6,9-trimethyl-2,3,6a,7,8,9,9a,9b-octahydro-6H-3a,6-epidioxyazuleno[4,5-b]furan-2-ol
  参考文献：
  名称：

  Design, Synthesis, and Development of Novel Guaianolide-Endoperoxides as Potential Antimalarial Agents

  摘要：

  Design and synthesis of a guaianolide-endoperoxide (thaperoxide) 3 was pursued as a new antimalarial lead which was found to be noncytotoxic as compared to the natural product lead thapsigargin 2. Several analogues of 3 were successfully synthesized and found to be comparable to derivatives of artemisinin 1 in in vitro antimalarial assay. Among the synthesized compounds, 22 showed excellent in vitro potency against the cultured parasites (W2 IC50 = 13 nM) without apparent cytotoxicity. Furthermore, SAR trends in thaperoxide analogues are presented and explained with the help of docking studies in the homology model of PfSERCA(PfATP6).

  DOI：

  10.1021/jm1006462
• 作为产物：
  描述：

  (3R,6aS,8S,9R,9aS,9br)-8-[(4-methoxybenzyl)oxy]-3,6,9-trimethyl-6a,7,8,9,9a,9b-hexahydroazuleno[4,5-b]furan-2(3H)-one 在 氧气 、 亚甲兰 作用下， 以 二氯甲烷 为溶剂， 以82%的产率得到(3R,3aS,6S,6aS,8S,9R,9aR,9br)-8-[(4-methoxybenzyl)oxy]-3,6,9-trimethyl-6a,7,8,9,9a,9bhexahydro-6H-3a,6-epidioxyazuleno[4,5-b]furan-2(3H)-one
  参考文献：
  名称：

  Design, Synthesis, and Development of Novel Guaianolide-Endoperoxides as Potential Antimalarial Agents

  摘要：

  Design and synthesis of a guaianolide-endoperoxide (thaperoxide) 3 was pursued as a new antimalarial lead which was found to be noncytotoxic as compared to the natural product lead thapsigargin 2. Several analogues of 3 were successfully synthesized and found to be comparable to derivatives of artemisinin 1 in in vitro antimalarial assay. Among the synthesized compounds, 22 showed excellent in vitro potency against the cultured parasites (W2 IC50 = 13 nM) without apparent cytotoxicity. Furthermore, SAR trends in thaperoxide analogues are presented and explained with the help of docking studies in the homology model of PfSERCA(PfATP6).

  DOI：

  10.1021/jm1006462

文献信息

• Design, Synthesis, and Development of Novel Guaianolide-Endoperoxides as Potential Antimalarial Agents
  作者：Lingzhi Sun、Falgun Shah、Mohamed A. Helal、Yunshan Wu、Yakambram Pedduri、Amar G. Chittiboyina、Jiri Gut、Philip J. Rosenthal、Mitchell A. Avery

  DOI：10.1021/jm1006462

  日期：2010.11.11

  Design and synthesis of a guaianolide-endoperoxide (thaperoxide) 3 was pursued as a new antimalarial lead which was found to be noncytotoxic as compared to the natural product lead thapsigargin 2. Several analogues of 3 were successfully synthesized and found to be comparable to derivatives of artemisinin 1 in in vitro antimalarial assay. Among the synthesized compounds, 22 showed excellent in vitro potency against the cultured parasites (W2 IC50 = 13 nM) without apparent cytotoxicity. Furthermore, SAR trends in thaperoxide analogues are presented and explained with the help of docking studies in the homology model of PfSERCA(PfATP6).