N-hexyl-2-hydroxy-2-phenylacetamide | 1613058-19-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-hexyl-2-hydroxy-2-phenylacetamide
• CAS: 1613058-19-7
• 化学式: C₁₄H₂₁NO₂
• 分子量: 235.326
• InChiKey: JBMSBCXZCZQLOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.42
• 重原子数：
  17.0
• 可旋转键数：
  7.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  49.33
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  正己胺 、 (±)-扁桃酰胺 在 niobium(V) oxide 作用下， 以 neat (no solvent) 为溶剂， 以74%的产率得到N-hexyl-2-hydroxy-2-phenylacetamide
  参考文献：
  名称：

  介孔氧化铌球作为伯酰胺与胺转氨的有效催化剂

  摘要：

  AbstractMesoporous niobium oxide spheres (MNOS), conveniently prepared by a novel antisolvent precipitation approach, have been shown to be an effective catalyst for the transamidation of primary amides with amines. This novel transamidation can be efficiently carried out under solvent‐free conditions and is applicable to a wide range of primary amides and amines to provide N‐alkyl amides in good to excellent yields. The catalyst is highly stable and reusable. The application of this transamidation reaction has been demonstrated in the synthesis of antidepressant drug moclobemide and other drug‐like compounds.magnified image

  DOI：

  10.1002/adsc.201300717

文献信息

• Methyltrimethoxysilane (MTM) as a Reagent for Direct Amidation of Carboxylic Acids
  作者：D. Christopher Braddock、Joshua J. Davies、Paul D. Lickiss

  DOI：10.1021/acs.orglett.1c04265

  日期：2022.2.11

  reagent for the direct amidation of carboxylic acids with amines. Two simple workup procedures that provide the pure amide product without the need for further purification have been developed. The first employs an aqueous base-mediated annihilation of MTM. The second involves simple product crystallization from the reaction mixture providing a low process mass intensity direct amidation protocol.

  甲基三甲氧基硅烷 [MTM, CH 3 Si(OMe) 3 ] 已被证明是一种有效、廉价且安全的试剂，可用于羧酸与胺的直接酰胺化。已经开发了两种无需进一步纯化即可提供纯酰胺产品的简单后处理程序。第一种采用水性碱介导的 MTM 湮灭。第二个涉及从反应混合物中简单的产物结晶，提供低工艺质量强度的直接酰胺化方案。