5-Phenyl-pentadiin-(2,4)-al | 18124-70-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-Phenyl-pentadiin-(2,4)-al
• 英文别名: 5-Phenylpenta-2,4-diynal
• CAS: 18124-70-4
• 化学式: C₁₁H₆O
• 分子量: 154.168
• InChiKey: JOXWZKHTQDFFAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-Phenyl-pentadiin-(2,4)-al 、 对甲苯磺酰肼 以 二氯甲烷 为溶剂， 以0.3336 g的产率得到5-phenyl-penta-2,4-diynal tosylhydrazone
  参考文献：
  名称：

  Synthesis of Simple Diynals, Diynones, Their Hydrazones, and Diazo Compounds: Precursors to a Family of Dialkynyl Carbenes (R¹—C≡C—C̈—C≡C—R²)

  摘要：

  A variety of substituted pentadiynols, -diynals, and -diynones have been prepared en route to precursors to dialkynyl carbenes (R-1-C C-C-C C-R-2). In light of the marginal stability associated with these simple systems, several strategies were required to assemble the carbon backbones. The requisite five-carbon skeletons were prepared using 4 + 1, 3 2, 2 + 2 + 1, and 2 + 1 + 1 + 1 coupling methodologies. The Dess Martin periodinane serves as an excellent method for the oxidation of pentadiynols to diynals and diynones, although many of the oxidized products are sufficiently reactive that they were not isolated; rather, they were generated in situ and intercepted with nucleophiles such as tosylhydrazide or trisylhydrazide. The hydrazone derivatives are generally reliable precursors to diazo compounds and carbenes, although cyclization of the hydrazone to afford a pyrazole can be a complicating factor in certain instances.

  DOI：

  10.1021/jo101125y
• 作为产物：
  描述：

  5-phenyl-2,4-pentadiyn-1-ol 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 5-Phenyl-pentadiin-(2,4)-al
  参考文献：
  名称：

  Synthesis of Simple Diynals, Diynones, Their Hydrazones, and Diazo Compounds: Precursors to a Family of Dialkynyl Carbenes (R¹—C≡C—C̈—C≡C—R²)

  摘要：

  A variety of substituted pentadiynols, -diynals, and -diynones have been prepared en route to precursors to dialkynyl carbenes (R-1-C C-C-C C-R-2). In light of the marginal stability associated with these simple systems, several strategies were required to assemble the carbon backbones. The requisite five-carbon skeletons were prepared using 4 + 1, 3 2, 2 + 2 + 1, and 2 + 1 + 1 + 1 coupling methodologies. The Dess Martin periodinane serves as an excellent method for the oxidation of pentadiynols to diynals and diynones, although many of the oxidized products are sufficiently reactive that they were not isolated; rather, they were generated in situ and intercepted with nucleophiles such as tosylhydrazide or trisylhydrazide. The hydrazone derivatives are generally reliable precursors to diazo compounds and carbenes, although cyclization of the hydrazone to afford a pyrazole can be a complicating factor in certain instances.

  DOI：

  10.1021/jo101125y

文献信息

• CHAIN MULTIYNE COMPOUND, PREPARATION METHOD AND APPLICATION THEREOF
  申请人：Xiamen University

  公开号：US20180065908A1

  公开（公告）日：2018-03-08

  The present invention relates to fields of organic chemistry and organometallic chemistry. The present invention discloses a chain multiyne compound, a preparation method thereof and an application in synthesizing a fused-ring metallacyclic compound. A structure of the chain multiyne compound in the present invention is shown as Formula I below. The present invention also provides a preparation method of the chain multiyne compound and an application thereof in a synthesis of a fused-ring metallacyclic compound. The chain multiyne compound disclosed in the present invention has multiple functional groups and the structure of the chain multiyne compound is adjustable. The chain multiyne compound can also be used to synthesize the fused-ring metallacyclic compound efficiently. The preparation method of the chain multiyne compound disclosed in the present invention is simple, which can be used to prepare the chain multiyne compound rapidly and efficiently.

  本发明涉及有机化学和有机金属化学领域。本发明公开了一种链状多炔化合物，其制备方法及在合成融环金属环化合物中的应用。本发明中的链状多炔化合物的结构如下式I所示。本发明还提供了链状多炔化合物的制备方法及其在合成融环金属环化合物中的应用。本发明公开的链状多炔化合物具有多个功能基团，其结构可调整。链状多炔化合物还可用于高效合成融环金属环化合物。本发明公开的链状多炔化合物的制备方法简单，可用于快速高效地制备链状多炔化合物。
• Chain multiyne compound, preparation method and application thereof
  申请人：Xiamen University

  公开号：US10287225B2

  公开（公告）日：2019-05-14

  The present invention relates to fields of organic chemistry and organometallic chemistry. The present invention discloses a chain multiyne compound, a preparation method thereof and an application in synthesizing a fused-ring metallacyclic compound. A structure of the chain multiyne compound in the present invention is shown as Formula I below. The present invention also provides a preparation method of the chain multiyne compound and an application thereof in a synthesis of a fused-ring metallacyclic compound. The chain multiyne compound disclosed in the present invention has multiple functional groups and the structure of the chain multiyne compound is adjustable. The chain multiyne compound can also be used to synthesize the fused-ring metallacyclic compound efficiently. The preparation method of the chain multiyne compound disclosed in the present invention is simple, which can be used to prepare the chain multiyne compound rapidly and efficiently.

  本发明涉及有机化学和有机金属化学领域。本发明公开了一种链状多炔化合物、其制备方法以及在合成熔环茂金属化合物中的应用。本发明中链多炔化合物的结构如下式 I 所示。本发明还提供了链式多炔化合物的制备方法及其在合成熔环茂金属环化合物中的应用。本发明公开的链式多炔化合物具有多个官能团，且链式多炔化合物的结构可调。该链多炔化合物还可用于高效合成熔环茂金属环化合物。本发明公开的链式多炔化合物的制备方法简单，可用于快速高效地制备链式多炔化合物。
• Gorgues,A., Bulletin de la Societe Chimique de France, 1974, p. 529 - 530
  作者：Gorgues,A.

  DOI：——

  日期：——
• Macrides, Theodore A.; Thaller, Viktor, Journal of Chemical Research, Miniprint, 1981, # 6, p. 2001 - 2016
  作者：Macrides, Theodore A.、Thaller, Viktor

  DOI：——

  日期：——
• Synthesis of Simple Diynals, Diynones, Their Hydrazones, and Diazo Compounds: Precursors to a Family of Dialkynyl Carbenes (R¹—C≡C—C̈—C≡C—R²)
  作者：Nathan P. Bowling、Nicola J. Burrmann、Robert J. Halter、Jonathan A. Hodges、Robert J. McMahon

  DOI：10.1021/jo101125y

  日期：2010.10.1

  A variety of substituted pentadiynols, -diynals, and -diynones have been prepared en route to precursors to dialkynyl carbenes (R-1-C C-C-C C-R-2). In light of the marginal stability associated with these simple systems, several strategies were required to assemble the carbon backbones. The requisite five-carbon skeletons were prepared using 4 + 1, 3 2, 2 + 2 + 1, and 2 + 1 + 1 + 1 coupling methodologies. The Dess Martin periodinane serves as an excellent method for the oxidation of pentadiynols to diynals and diynones, although many of the oxidized products are sufficiently reactive that they were not isolated; rather, they were generated in situ and intercepted with nucleophiles such as tosylhydrazide or trisylhydrazide. The hydrazone derivatives are generally reliable precursors to diazo compounds and carbenes, although cyclization of the hydrazone to afford a pyrazole can be a complicating factor in certain instances.