9-bromo-5,6,8,9,10,11-hexahydro-7H-5,9:7,11-dimethanobenzo[9]annulen-7-amine | 1607472-80-9

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 9-bromo-5,6,8,9,10,11-hexahydro-7H-5,9:7,11-dimethanobenzo[9]annulen-7-amine
• 英文别名: 12-Bromotetracyclo[8.3.1.18,12.02,7]pentadeca-2,4,6-trien-10-amine
• CAS: 1607472-80-9
• 化学式: C₁₅H₁₈BrN
• 分子量: 292.219
• InChiKey: GOPPKVLPBNHOPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  9-bromo-5,6,8,9,10,11-hexahydro-7H-5,9:7,11-dimethanobenzo[9]annulen-7-amine 在 偶氮二异丁腈 、 三正丁基氢锡 、 盐酸 作用下， 以 甲苯 、 二氯甲烷 、 水 为溶剂， 反应 2.5h， 以73 mg的产率得到5,6,8,9,10,11-hexahydro-7H-5,9:7,11-dimethanobenzo[9]annulen-7-amine hydrochloride
  参考文献：
  名称：

  Novel benzopolycyclic amines with NMDA receptor antagonist activity

  摘要：

  A new series of benzopolycyclic amines active as NMDA receptor antagonists were synthesized. Most of them exhibited increased activity compared with related analogues previously published. All the tested compounds were more potent than clinically approved amantadine and one of them displayed a lower IC50 value than memantine, an anti-Alzheimer's approved drug. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2014.03.025
• 作为产物：
  描述：

  11-methylene-5,6,8,9-tetrahydro-5,9-propano-7H-benzocyclohepten-7-one 在 二溴亚砜 、 硫酸 、 hydrochloric acid diethyl ether 、 溶剂黄146 、 硫脲 作用下， 以 乙醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 1.5h， 生成 9-bromo-5,6,8,9,10,11-hexahydro-7H-5,9:7,11-dimethanobenzo[9]annulen-7-amine
  参考文献：
  名称：

  Novel benzopolycyclic amines with NMDA receptor antagonist activity

  摘要：

  A new series of benzopolycyclic amines active as NMDA receptor antagonists were synthesized. Most of them exhibited increased activity compared with related analogues previously published. All the tested compounds were more potent than clinically approved amantadine and one of them displayed a lower IC50 value than memantine, an anti-Alzheimer's approved drug. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2014.03.025

文献信息

• [EN] POLYCYCLIC COMPOUNDS AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS<br/>[FR] COMPOSÉS POLYCYCLIQUES EN TANT QU'INHIBITEURS D'ÉPOXYDE HYDROLASE SOLUBLE
  申请人：UNIV BARCELONA

  公开号：WO2019243414A1

  公开（公告）日：2019-12-26

  The present invention relates to soluble epoxide hydrolase (sEH) inhibitors of formula (I) to processes for their obtention and to their therapeutic indications.