Gamma-glutamyl-Hydroxyproline | 1801529-32-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Gamma-glutamyl-Hydroxyproline
• 英文别名: (2S,4R)-1-[(4S)-4-amino-4-carboxybutanoyl]-4-hydroxypyrrolidine-2-carboxylic acid
• CAS: 1801529-32-7
• 化学式: C₁₀H₁₆N₂O₆
• 分子量: 260.24
• InChiKey: VKENMLSUUVOQLD-VQVTYTSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.4
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  141
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• LABELED MOLECULAR IMAGING AGENTS AND METHODS OF USE
  申请人：General Electric Company

  公开号：US20150202333A1

  公开（公告）日：2015-07-23

  Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.

  描述了包含标记底物的成像剂，这些底物能够通过半胱氨酸/谷氨酸抗转运体引入细胞中。这些底物可用于通过通过半胱氨酸/谷氨酸抗转运体将标记的剂量引入细胞并进行后续检测，从而成像或检测细胞中的氧化应激。
• Genomic instability markers in Fanconi anemia
  申请人：Children's Hospital Medical Center

  公开号：US10857211B2

  公开（公告）日：2020-12-08

  Markers for genomic instability in Fanconi Anemia (FA) and other pathologies for therapeutic and diagnostic uses. In one embodiment, glycosphingolipid metabolism is altered in the FA deficient squamous cell carcinoma (SCC) cells, based on analysis of a metabolomics/lipidomics platform. The data indicated ganglioside metabolism was important in FA patients' susceptibility to SCC progression.

  用于治疗和诊断的范可尼贫血症（FA）和其他病症基因组不稳定性的标记物。在一个实施方案中，根据代谢组学/脂质组学平台的分析，FA 缺陷鳞状细胞癌（SCC）细胞中的糖磷脂代谢发生了改变。数据表明，神经节苷脂代谢在 FA 患者易患 SCC 的过程中起着重要作用。
• GENOMIC INSTABILITY MARKERS IN FANCONI ANEMIA
  申请人：Children's Hospital Medical Center

  公开号：US20170100462A1

  公开（公告）日：2017-04-13

  Markers for genomic instability in Fanconi Anemia (FA) and other pathologies for therapeutic and diagnostic uses. In one embodiment, glycosphingolipid metabolism is altered in the FA deficient squamous cell carcinoma (SCC) cells, based on analysis of a metabolomics/lipidomics platform. The data indicated ganglioside metabolism was important in FA patients' susceptibility to SCC progression.
• US9468693B2
  申请人：——

  公开号：US9468693B2

  公开（公告）日：2016-10-18
• [EN] LABELED MOLECULAR AGENTS FOR IMAGING CYSTINE/GLUTAMATE ANTI PORTER<br/>[FR] AGENTS MOLÉCULAIRES MARQUÉS POUR IMAGERIE VIA L'ANTIPORT CYSTINE/GLUTAMATE
  申请人：GEN ELECTRIC

  公开号：WO2015112333A1

  公开（公告）日：2015-07-30

  Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.