N-(3-chlorobenzyl)-9H-benzo[b]pyrido[3,2-f]pyrimido[5,4-d]azepin-2-amine | 1246547-07-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: N-(3-chlorobenzyl)-9H-benzo[b]pyrido[3,2-f]pyrimido[5,4-d]azepin-2-amine
• 英文别名: N-[(3-chlorophenyl)methyl]-3,5,14,16-tetrazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(15),2,4,6,8,10,12,16,18-nonaen-4-amine
• CAS: 1246547-07-8
• 化学式: C₂₂H₁₆ClN₅
• 分子量: 385.856
• InChiKey: XVZQJUHZSBYKCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  62.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (E)-6-((dimethylamino)methylene)-6,11-dihydro-5H-benzo[f]pyrido[2,3-b]azepin-5-one 、 3-Chlorobenzylguanidine hydrochloride 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 生成 N-(3-chlorobenzyl)-9H-benzo[b]pyrido[3,2-f]pyrimido[5,4-d]azepin-2-amine
  参考文献：
  名称：

  SUBSTITUTED DIPYRIDO-PYRIMIDO-DIAZEPINE AND BENZO-PYRIDO-PYRIMIDO COMPOUNDS

  摘要：

  本发明涉及取代的二吡咯-嘧啶-二氮杂环化合物，取代的苯并-二吡咯-嘧啶-二氮杂环化合物以及合成这些化合物的方法。本发明还涉及含有取代的二吡咯-嘧啶-二氮杂环化合物，取代的苯并-二吡咯-嘧啶-二氮杂环化合物的药物组合物，并通过将这些化合物和药物组合物给予需要的受体中，治疗细胞增殖性疾病，如癌症的方法。

  公开号：

  US20100249108A1

文献信息

• Substituted dipyrido-pyrimido-diazepine and benzo-pyrido-pyrimido compounds
  申请人：ArQule, Inc.

  公开号：US08349827B2

  公开（公告）日：2013-01-08

  The present invention relates to substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及替代二吡啶嘧啶-二氮杂环化合物、替代苯并二吡啶嘧啶-二氮杂环化合物及其合成方法。本发明还涉及含有替代二吡啶嘧啶-二氮杂环化合物、替代苯并二吡啶嘧啶-二氮杂环化合物的药物组合物，并通过将这些化合物和药物组合物用于需要治疗细胞增殖性疾病（如癌症）的受试者来治疗这些疾病的方法。
• US8349827B2
  申请人：——

  公开号：US8349827B2

  公开（公告）日：2013-01-08
• [EN] SUBSTITUTED DIPYRIDO-PYRIMIDO-DIAZEPINE AND BENZO-PYRIDO-PYRIMIDO COMPOUNDS<br/>[FR] COMPOSÉS DIPYRIDO-PYRIMIDO-DIAZÉPINE ET BENZO-PYRIDO-PYRIMIDO SUBSTITUÉS
  申请人：ARQULE INC

  公开号：WO2010114898A1

  公开（公告）日：2010-10-07

  The present invention relates to substituted dipyrido-pyrimido-diazepine compounds of formula (I), substituted benzo-pyrido-pyrimido-diazepine compounds of formula (I) and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido- diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
• SUBSTITUTED DIPYRIDO-PYRIMIDO-DIAZEPINE AND BENZO-PYRIDO-PYRIMIDO COMPOUNDS
  申请人：Tandon Manish

  公开号：US20100249108A1

  公开（公告）日：2010-09-30

  The present invention relates to substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及取代的二吡咯-嘧啶-二氮杂环化合物，取代的苯并-二吡咯-嘧啶-二氮杂环化合物以及合成这些化合物的方法。本发明还涉及含有取代的二吡咯-嘧啶-二氮杂环化合物，取代的苯并-二吡咯-嘧啶-二氮杂环化合物的药物组合物，并通过将这些化合物和药物组合物给予需要的受体中，治疗细胞增殖性疾病，如癌症的方法。