(S)-2-amino-4-methyl-1-thiomorpholinopentan-1-one hydrochloride | 1312582-27-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-amino-4-methyl-1-thiomorpholinopentan-1-one hydrochloride
• CAS: 1312582-27-6
• 化学式: C₁₀H₂₀N₂OS*ClH
• 分子量: 252.809
• InChiKey: QMUSTQIZRJWCOE-FVGYRXGTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.36
• 重原子数：
  15.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  46.33
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  L-亮氨酸 在 盐酸 、 乙酸乙酯 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 sodium hydroxide 作用下， 生成 (S)-2-amino-4-methyl-1-thiomorpholinopentan-1-one hydrochloride
  参考文献：
  名称：

  Design, synthesis and primary activity of thiomorpholine derivatives as DPP-IV inhibitors

  摘要：

  Thirteen thiomorpholine-bearing compounds were designed and synthesized as dipeptidyl peptidase IV (DPP-IV) inhibitors, with natural and non-natural L-amino acids as the starting materials. Their structures were characterized by H-1 NMR, C-13 NMR and HR-MS. The target compounds were screened for the DPP-IV inhibition, and the preliminary SAR result was obtained. Particularly, compounds 4c, 4d and 4f with good DPP-IV inhibition in vitro were further evaluated through a mouse oral glucose tolerance test (OGTT). The preliminary result showed the potential value for further studies on those thiomorpholine-bearing compounds as DPP-IV inhibitors. (C) 2011 Hai Hong Huang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2011.12.007