(8S,9S,10R,13S,14S,16S,17R)-16-(tert-Butyl-dimethyl-silanyloxy)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one | 439587-86-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (8S,9S,10R,13S,14S,16S,17R)-16-(tert-Butyl-dimethyl-silanyloxy)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
• CAS: 439587-86-7
• 化学式: C₃₃H₅₈O₂Si
• 分子量: 514.908
• InChiKey: BVJIVPFKNSSBCU-ASCKHUKSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  36.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (8S,9S,10R,13S,14S,16S,17R)-16-(tert-Butyl-dimethyl-silanyloxy)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 在 咪唑 、 lithium aluminium tetrahydride 、 dimethyl bromohydantoin 、 potassium tert-butylate 作用下， 以 四氢呋喃 、 正己烷 、 N,N-二甲基甲酰胺 、 叔丁醇 、 苯 为溶剂， 生成 3β,16β-bis(tert-butyldimethylsilyloxy)-4,4-dimethylcholesta-5,7-diene
  参考文献：
  名称：

  Meiosis activating sterols derived from diosgenin

  摘要：

  Continuing research based on the meiosis activation properties of the endogenous sterol FF-MAS is reported. The synthesis and SAR of 16- and 26-substituted sterols are described, utilising diosgenin as starting material. Selected sterols were tested for their ability to induce oocyte maturation in hypoxanthine arrested mouse oocytes in vitro. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00840-x
• 作为产物：
  描述：

  16β-(tert-butyldimethylsilyloxy)cholest-5-en-3β-ol 在 N-甲基吗啉 、 aluminum isopropoxide 作用下， 以90%的产率得到(8S,9S,10R,13S,14S,16S,17R)-16-(tert-Butyl-dimethyl-silanyloxy)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
  参考文献：
  名称：

  Meiosis activating sterols derived from diosgenin

  摘要：

  Continuing research based on the meiosis activation properties of the endogenous sterol FF-MAS is reported. The synthesis and SAR of 16- and 26-substituted sterols are described, utilising diosgenin as starting material. Selected sterols were tested for their ability to induce oocyte maturation in hypoxanthine arrested mouse oocytes in vitro. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00840-x