5-acetamido-2,6-anhydro-4-(3-carboxypropyl)amino-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid | 1236306-67-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-acetamido-2,6-anhydro-4-(3-carboxypropyl)amino-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid
• 英文别名: (2R,3R,4S)-3-acetamido-4-(3-carboxypropylamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
• CAS: 1236306-67-4
• 化学式: C₁₅H₂₄N₂O₉
• 分子量: 376.364
• InChiKey: GUMHCHWXXZOMDM-ZZEHVWSGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.7
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  186
• 氢给体数：
  7
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  5-acetamido-7,8,9-tri-O-acetyl-2,6-anhydro-4-(3-methxycarbonyl)propylamino-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid methyl ester 在 水 、 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 0.5h， 以79%的产率得到5-acetamido-2,6-anhydro-4-(3-carboxypropyl)amino-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid
  参考文献：
  名称：

  Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses

  摘要：

  Unlike the group-2 neuraminidase, the group-1 neuraminidase of influenza virus possesses a flexible loop (the 150-loop) and a cavity (the 150-cavity) adjacent to the active site, and renders a conformational change from the 'open' form to the 'closed' form on binding with substrate (sialo-glycoprotein) or inhibitor (e.g., zanamivir). Zanamivir derivative 8a having an extended (piperazinocarbonyl)propyl substituent at the internal N-position of the guanidino group is designed as a possible inhibitor on the basis of computer docking to the open form of N1 subtype neuraminidase. Indeed, compound 8a exhibits strong neuraminidase inhibition and good anti-influenza activity against H1N1 virus with IC(50) = 2.15 mu M and EC(50) = 0.77 mu M, respectively. This study may provide a clue to future design of better group-1 neuraminidase inhibitors. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.04.010

文献信息

• Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses
  作者：Wen-Hsien Wen、Shi-Yun Wang、Keng-Chang Tsai、Yih-Shyun E. Cheng、An-Suei Yang、Jim-Min Fang、Chi-Huey Wong

  DOI：10.1016/j.bmc.2010.04.010

  日期：2010.6.1

  Unlike the group-2 neuraminidase, the group-1 neuraminidase of influenza virus possesses a flexible loop (the 150-loop) and a cavity (the 150-cavity) adjacent to the active site, and renders a conformational change from the 'open' form to the 'closed' form on binding with substrate (sialo-glycoprotein) or inhibitor (e.g., zanamivir). Zanamivir derivative 8a having an extended (piperazinocarbonyl)propyl substituent at the internal N-position of the guanidino group is designed as a possible inhibitor on the basis of computer docking to the open form of N1 subtype neuraminidase. Indeed, compound 8a exhibits strong neuraminidase inhibition and good anti-influenza activity against H1N1 virus with IC(50) = 2.15 mu M and EC(50) = 0.77 mu M, respectively. This study may provide a clue to future design of better group-1 neuraminidase inhibitors. (C) 2010 Elsevier Ltd. All rights reserved.