tert-butyl N-[(2S)-1-[(2S,4R)-2-[[(1R,2R)-2-ethyl-1-[(1-pent-4-enylcyclopropyl)sulfonylcarbamoyl]cyclopropyl]carbamoyl]-4-[1-propan-2-yl-4-(prop-2-enylcarbamoyl)benzimidazol-2-yl]oxypyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate | 1365749-33-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl N-[(2S)-1-[(2S,4R)-2-[[(1R,2R)-2-ethyl-1-[(1-pent-4-enylcyclopropyl)sulfonylcarbamoyl]cyclopropyl]carbamoyl]-4-[1-propan-2-yl-4-(prop-2-enylcarbamoyl)benzimidazol-2-yl]oxypyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
• CAS: 1365749-33-2
• 化学式: C₄₄H₆₅N₇O₉S
• 分子量: 868.108
• InChiKey: IRMUWVVROIYNHJ-NWJXIVSPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  61
• 可旋转键数：
  21
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  216
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• [EN] NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION<br/>[FR] NOUVEAUX INHIBITEURS DE LA RÉPLICATION DU VIRUS DE L'HÉPATITE C
  申请人：INTERMUNE INC

  公开号：WO2012037259A1

  公开（公告）日：2012-03-22

  The invention relates to macrocyclic compounds of Formula e I. (in which the variables are as defined herein) for use in the treatment of hepatitis C virus. Therapeutic methods, medicaments and dosage forms related thereto are also disclosed.

  该发明涉及用于治疗丙型肝炎病毒的式I的大环化合物（其中变量如本文所定义）。还公开了与之相关的治疗方法、药物和剂型。
• [EN] THERAPEUTIC ANTIVIRAL PEPTIDES<br/>[FR] PEPTIDES ANTIVIRAUX THÉRAPEUTIQUES
  申请人：INTERMUNE INC

  公开号：WO2012047764A1

  公开（公告）日：2012-04-12

  The invention relates to compounds of Formula (I) (in which the variables are defined as herein) and compositions, including pharmaceutical compositions, thereof. The invention further provides treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis through administering to an individual in need thereof an effective amount of a subject compound or composition.