(R)-3-methoxy-1-(5-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)isoindolin-2-yl)propan-1-one hydrochloride | 1181690-62-9

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: (R)-3-methoxy-1-(5-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)isoindolin-2-yl)propan-1-one hydrochloride
• 英文别名: 3-methoxy-1-[5-[4-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]phenyl]-1,3-dihydroisoindol-2-yl]propan-1-one;hydrochloride
• CAS: 1181690-62-9
• 化学式: C₂₅H₃₂N₂O₂*ClH
• 分子量: 429.002
• InChiKey: NQOXRWDQTZVEKQ-FSRHSHDFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.68
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  32.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• MODULATORS OF THE HISTAMINE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
  申请人：Santora Vincent J.

  公开号：US20100331312A1

  公开（公告）日：2010-12-30

  Amide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-associated disorders, such as cognitive disorders, epilepsy, brain trauma, depression, obesity, disorders of sleep and wakefulness such as excessive daytime sleepiness, narcolepsy, shift-work sleep disorder, drowsiness as a side effect from a medication, maintenance of vigilance to aid in the completion of tasks and the like, cataplexy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease, pain and the like.

  化合物(Ia)的酰胺衍生物及其制药组合物，可以调节组胺H3受体的活性。本发明的化合物和制药组合物适用于治疗组胺H3相关疾病的方法，如认知障碍、癫痫、脑创伤、抑郁症、肥胖症、睡眠和清醒障碍疾病，如白天过度嗜睡、嗜睡症、轮班工作睡眠障碍、药物副作用引起的嗜睡、保持警觉以帮助完成任务等，猝倒、过度睡眠、嗜睡综合症、时差反应、睡眠呼吸暂停等、注意力缺陷多动障碍(ADHD)、精神分裂症、过敏症、上呼吸道过敏反应、过敏性鼻炎、鼻塞、痴呆症、阿尔茨海默病、疼痛等。