2,5-anhydro-1-deoxy-1-(uracil-1'-yl)-6-(5''-(4'''-(N-L-prolinyl-N'-amidomethyl)-1H,1''',2''',3'''-triazol-1'''-yl)-1'',5''-dideoxy-2'',3''-O-isopentylidene-β-D-ribos-1''-yl)-D-glucitol | 1237748-16-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,5-anhydro-1-deoxy-1-(uracil-1'-yl)-6-(5''-(4'''-(N-L-prolinyl-N'-amidomethyl)-1H,1''',2''',3'''-triazol-1'''-yl)-1'',5''-dideoxy-2'',3''-O-isopentylidene-β-D-ribos-1''-yl)-D-glucitol
• 英文别名: (2S)-N-[[1-[[(2R,3S,4R,5R)-5-[[(2R,3S,4S,5S)-5-[(2,4-dioxopyrimidin-1-yl)methyl]-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxyoxolan-2-yl]methyl]triazol-4-yl]methyl]pyrrolidine-2-carboxamide
• CAS: 1237748-16-1
• 化学式: C₂₃H₃₃N₇O₁₀
• 分子量: 567.556
• InChiKey: OUZUJFXDOISSHW-BYHBZOCWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.1
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  230
• 氢给体数：
  7
• 氢受体数：
  13

反应信息

• 作为产物：
  描述：

  2,5-anhydro-1-deoxy-1-(uracil-1'-yl)-6-(5''-(4'''-(N-Boc-L-prolinyl-N'-amidomethyl)-1H,1''',2''',3'''-triazol-1'''-yl)-1'',5''-dideoxy-2'',3''-O-isopentylidene-β-D-ribos-1''-yl)-D-glucitol 在 水 、 三氟乙酸 作用下， 以64%的产率得到2,5-anhydro-1-deoxy-1-(uracil-1'-yl)-6-(5''-(4'''-(N-L-prolinyl-N'-amidomethyl)-1H,1''',2''',3'''-triazol-1'''-yl)-1'',5''-dideoxy-2'',3''-O-isopentylidene-β-D-ribos-1''-yl)-D-glucitol
  参考文献：
  名称：

  Bacterial transferase MraY inhibitors: Synthesis and biological evaluation

  摘要：

  New inhibitors of the bacterial transferase MraY are described. Their structure is based on an aminoribosyl-O-uridine like scaffold, readily obtained in two key steps. The amino group can be coupled with proline or guanylated. Alternatively, these amino, prolinyl or guanidinyl groups can be introduced through a triazole linker. Biological evaluation of these compounds on MraY from Bacillus subtilis revealed interesting inhibitory activity for both amino compounds. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2010.04.023

文献信息

• Bacterial transferase MraY inhibitors: Synthesis and biological evaluation
  作者：Delphine Lecerclé、Anthony Clouet、Bayan Al-Dabbagh、Muriel Crouvoisier、Ahmed Bouhss、Christine Gravier-Pelletier、Yves Le Merrer

  DOI：10.1016/j.bmc.2010.04.023

  日期：2010.6.15

  New inhibitors of the bacterial transferase MraY are described. Their structure is based on an aminoribosyl-O-uridine like scaffold, readily obtained in two key steps. The amino group can be coupled with proline or guanylated. Alternatively, these amino, prolinyl or guanidinyl groups can be introduced through a triazole linker. Biological evaluation of these compounds on MraY from Bacillus subtilis revealed interesting inhibitory activity for both amino compounds. (C) 2010 Published by Elsevier Ltd.