N-(E)-Feruoyl-L-tyrosine amide | 731773-64-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(E)-Feruoyl-L-tyrosine amide
• 英文别名: (2S)-2-[[(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]amino]-3-(4-hydroxyphenyl)propanoic acid
• CAS: 731773-64-1
• 化学式: C₁₉H₁₉NO₆
• 分子量: 357.4
• InChiKey: RWAXPZCUFIKMTQ-BOSPYUDASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Genetically altered alfalfa producing clovamide and/or related hydroxycinnamoyl amides
  申请人：The United States of America, as represented by the Secretary of Agriculture

  公开号：US10253324B2

  公开（公告）日：2019-04-09

  Two novel cDNAs for two different genes, HDT1 and HDT2, are isolated from red clover and sequenced. Both HDT1 and HDT2 encode hydroxycinnamoyl-CoA:L-DOPA/tyrosine hydroxycinnamoyl transferase (HDT) which enzymatically produces clovamide and/or related hydroxycinnamoyl amides. Clovamide and related hydroxycinnamoyl amides reduce post-harvest protein degradation. Genetically altered alfalfa plants containing an expression cassette containing a cDNA encoding HDT1 or HDT2 are generated. These genetically altered alfalfa plants produce hydroxycinnamoyl-CoA:L-DOPA/tyrosine hydroxycinnamoyl transferase, which in turn produces clovamide and/or related hydroxycinnamoyl amides.

  从红三叶中分离出两个不同基因 HDT1 和 HDT2 的新型 cDNA，并对其进行了测序。HDT1 和 HDT2 都编码羟基肉桂酰-CoA:L-DOPA/酪氨酸羟基肉桂酰转移酶（HDT），它能酶促产生氯酰胺和/或相关的羟基肉桂酰酰胺。氯酰胺和相关的羟基肉桂酰酰胺可减少收获后蛋白质的降解。基因改变的苜蓿植株含有一个表达盒，其中包含编码 HDT1 或 HDT2 的 cDNA。这些基因改变的苜蓿植物会产生羟基肉桂酰-CoA:L-DOPA/酪氨酸羟基肉桂酰转移酶，进而产生氯酰胺和/或相关的羟基肉桂酰酰胺。
• PRODUCTS COMPRISING N-PHENYLPROPENOYL AMINO ACID AMIDES AND USES THEREOF
  申请人：Nestec S.A.

  公开号：EP2396083A2

  公开（公告）日：2011-12-21
• GENETICALLY ALTERED ALFALFA PRODUCING CLOVAMIDE AND/OR RELATED HYDROXYCINNAMOYL AMIDES
  申请人：The United States of America, as represented by the Secretary of Agriculture

  公开号：US20170088847A1

  公开（公告）日：2017-03-30

  Two novel cDNAs for two different genes, HDT1 and HDT2, are isolated from red clover and sequenced. Both HDT1 and HDT2 encode hydroxycinnamoyl-CoA:L-DOPA/tyrosine hydroxycinnamoyl transferase (HDT) which enzymatically produces clovamide and/or related hydroxycinnamoyl amides. Clovamide and related hydroxycinnamoyl amides reduce post-harvest protein degradation. Genetically altered alfalfa plants containing an expression cassette containing a cDNA encoding HDT1 or HDT2 are generated. These genetically altered alfalfa plants produce hydroxycinnamoyl-CoA:L-DOPA/tyrosine hydroxycinnamoyl transferase, which in turn produces clovamide and/or related hydroxycinnamoyl amides.
• [EN] PRODUCTS COMPRISING N-PHENYLPROPENOYL AMINO ACID AMIDES AND USES THEREOF<br/>[FR] PRODUITS COMPRENANT DES AMIDES D'ACIDE AMINÉ N-PHÉNYLPROPÉNOYLE ET UTILISATIONS DE CEUX-CI
  申请人：NESTEC SA

  公开号：WO2010091981A2

  公开（公告）日：2010-08-19

  The present invention relates to use of a composition comprising N-phenylpropenoyl amino acid amides for the preparation of a product to treat or prevent neurodegenerative disorders, cognitive decline, mild cognitive impairment, dementia, mood disorders, depression, sleep disorders, diseases involving protein aggregation in a human or animal, Alzheimer's disease, macular degeneration or diabetes. The invention further relates to products comprising N-phenylpropenoyl amino acid amides, including food and beverage products, food supplements, and pet food products, and methods for affecting cognitive performance of humans and animals.