3-溴-2-氟-4-甲基吡啶 | 884495-46-9

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 3-溴-2-氟-4-甲基吡啶
• 英文名称: 3-Bromo-2-fluoro-4-methylpyridine
• CAS: 884495-46-9
• 化学式: C₆H₅BrFN
• 分子量: 190.01
• InChiKey: SXBCGEAJVXDYBL-UHFFFAOYSA-N

物化性质

• 沸点：
  210.5±35.0 °C(Predicted)
• 密度：
  1.592±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Fused Heterocyclic Compounds as Selective BMP Inhibitors
  申请人：VANDERBILT UNIVERSITY

  公开号：US20160068525A1

  公开（公告）日：2016-03-10

  The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.

  本发明提供了BMP信号通路的小分子抑制剂。这些化合物可用于调节细胞生长、分化、增殖和凋亡，因此可用于治疗与BMP信号通路相关的疾病或情况，包括炎症、心血管疾病、血液病、癌症和骨骼疾病，以及用于调节细胞分化和/或增殖。
• Substituted Macrocyclic Compounds and Related Methods of Treatment
  申请人：Alkermes, Inc.

  公开号：US20220194958A1

  公开（公告）日：2022-06-23

  The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

  本发明提供了一种用于治疗患有嗜睡症或弛缓症的化合物，以及相关的制药组合物和方法。
• 2,4,6,7-TETRAHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-5-ONE DERIVATIVES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS FOR TREATING VASCULITIS AND INFLAMMATORY DISEASES
  申请人：Idorsia Pharmaceuticals Ltd.

  公开号：US20200369672A1

  公开（公告）日：2020-11-26

  The present invention relates to derivatives of formula (I) wherein Ring A, X, Y, Z, R A , R 1 , R 2 , R 3 and R 4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators.
• [EN] SUBSTITUTED MACROCYCLIC COMPOUNDS AND RELATED METHODS OF TREATMENT<br/>[FR] COMPOSÉS MACROCYCLIQUES SUBSTITUÉS ET PROCÉDÉS DE TRAITEMENT ASSOCIÉS
  申请人：[en]ALKERMES, INC.

  公开号：WO2022140316A1

  公开（公告）日：2022-06-30

  The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.