(S)-2-(2-chloro-5-trifluoromethyl-benzenesulfonylamino)-3-(1H-indol-3-yl)-2-methyl-N-(1-pyridin-2-yl-cyclohexylmethyl)-propionamide | 428864-66-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-(2-chloro-5-trifluoromethyl-benzenesulfonylamino)-3-(1H-indol-3-yl)-2-methyl-N-(1-pyridin-2-yl-cyclohexylmethyl)-propionamide
• 英文别名: (2S)-2-[[2-chloro-5-(trifluoromethyl)phenyl]sulfonylamino]-3-(1H-indol-3-yl)-2-methyl-N-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide
• CAS: 428864-66-8
• 化学式: C₃₁H₃₂ClF₃N₄O₃S
• 分子量: 633.134
• InChiKey: SGXZWKBMZURBHA-LJAQVGFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  43
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Treatment of sexual dysfunction
  申请人：——

  公开号：US20020169101A1

  公开（公告）日：2002-11-14

  Bombesin receptor antagonists have been found to be useful in the treatment of sexual dysfunction in both males and females. They may be selective BB1 antagonists or mixed BB1/BB2 antagonists. Combinations are disclosed of bombesin receptor antagonists with a range of other active compounds, for example PDE5 inhibitors, NEP inhibitors and lasofoxifene.

  Bombesin受体拮抗剂已被发现在男性和女性的性功能障碍治疗中非常有用。它们可以是选择性BB1拮抗剂或混合BB1 / BB2拮抗剂。揭示了与一系列其他活性化合物的Bombesin受体拮抗剂的组合，例如PDE5抑制剂，NEP抑制剂和lasofoxifene。
• Bombesin receptor antagonists
  申请人：——

  公开号：US20040116440A1

  公开（公告）日：2004-06-17

  Bombesin receptor antagonists are provided which are useful for the diagnosis, prevention, or treatment of male sexual dysfunction in humans and animals, female sexual dysfunction in humans and animals, anxiety and panic disorders, social phobia, depression, psychoses, sleeping disorders, memory impairment, pulmonary hypertension, lung repair and lung development disorders, cancer including prostate cancer and pancreatic cancer, hepatic porphyria, gastrointestinal secretory disturbances, gastrointestinal disorders including colitis, Crohn's disease and inflammatory bowel disease, emesis, anorexia, pain, seasonal affective disorders, feeding disorders, or pruritus. The compounds of formula (I) or pharmaceutically acceptable salts thereof: 1 wherein k, l, m, n, X, Ar, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the description.

  提供了用于诊断、预防或治疗男性和动物的性功能障碍、女性和动物的性功能障碍、焦虑和惊恐障碍、社交恐惧症、抑郁症、精神病、睡眠障碍、记忆障碍、肺动脉高压、肺修复和肺发育障碍、包括前列腺癌和胰腺癌在内的癌症、肝卟啉病、胃肠分泌障碍、包括结肠炎、克隆氏病和炎症性肠病在内的胃肠疾病、呕吐、厌食、疼痛、季节性情感障碍、进食障碍或瘙痒症的炸弹肽受体拮抗剂，其中化合物的公式（I）或其药学上可接受的盐：1其中k，l，m，n，X，Ar，Ar1，R1，R2，R3，R4，R5和R6如描述中所定义。
• TREATMENT OF SEXUAL DYSFUNCTION WITH BOMBESIN RECEPTOR ANTAGONISTS
  申请人：Warner-Lambert Company LLC

  公开号：EP1333824B1

  公开（公告）日：2005-09-07
• TREATMENT OF SEXUAL DYSFUNCTION
  申请人：Warner-Lambert Company LLC

  公开号：EP1333824A2

  公开（公告）日：2003-08-13
• TREATMENT OF SEXUAL DYSFUNCTION USING BOMBESIN ANTAGONISTS
  申请人：Warner-Lambert Company LLC

  公开号：EP1333829A1

  公开（公告）日：2003-08-13