2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-propionic acid | 59237-81-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-propionic acid
• 英文别名: 2-(2,4-Dioxopyrimidin-1-yl)-3-hydroxypropanoic acid
• CAS: 59237-81-9
• 化学式: C₇H₈N₂O₅
• 分子量: 200.151
• InChiKey: ZYYUUDOITSMAMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] PREVENTING ISCHEMIA-INDUCED CELL DAMAGE<br/>[FR] PREVENTION DE DOMMAGES CELLULAIRES INDUITS PAR L'ISCHEMIE
  申请人：UNIV MIAMI

  公开号：WO2004009780A2

  公开（公告）日：2004-01-29

  Hypoxia-acidosis-associated cell death is mediated by BNIP3, a member of the Bcl-2 family of apoptosis-regulating proteins. Chronic hypoxia induced the expression and accumulation of BNIP3 mRNA and protein in cardiac myocytes but acidosis was required to activate the death pathway. Acidosis stabilized BNIP3 protein and increased the association with mitochondria. Cell death by hypoxia-acidosis was blocked by pretreatment with antisense BNIP3 oligonucleotides. The pathway included extensive DNA fragmentation and opening of the mitochondrial permeability transition pore but no apparent caspase activation. Overexpression of wild type BNIP3, but not a translocation-defective mutant activated cardiac myocyte death when the myocytes were acidotic or hypoxic.
• [EN] METHOD FOR DETECTING REMOTE HOMOLOGUES AND NOVEL KINASES IDENTIFIED WITH THE METHOD<br/>[FR] PROCEDE POUR DETECTER DES HOMOLOGUES ELOIGNES ET NOUVELLES KINASES IDENTIFIEES AU MOYEN DE CE PROCEDE
  申请人：GRIGORIEV IGOR VYACHESLAVOVICH

  公开号：WO2004069154A2

  公开（公告）日：2004-08-19

  The present invention relates to novel methods for detecting remote polypeptide homologues. The present invention relates to kinase polypeptides, nucleotide sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian kinases have been identified and their protein structure predicted.