[Pd(N,N'-dimethylbenzylamine)(NCO)(isonicotinamide)] | 1227465-88-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: [Pd(N,N'-dimethylbenzylamine)(NCO)(isonicotinamide)]
• 英文别名: [Pd(dmba)(NCO)(isn)]；Pd(N,N'-dimethylbenzylamine)(NCO)(isonicotinamide)；Pd(dmba)(NCO)(iso)
• CAS: 1227465-88-4
• 化学式: C₁₆H₁₈N₄O₂Pd
• 分子量: 404.765
• InChiKey: OUKFFRRSDXAZQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [Pd(N,N'-dimethylbenzylamine)(NCO)(isonicotinamide)] 以 neat (no solvent) 为溶剂， 生成 钯
  参考文献：
  名称：

  Thermal and spectroscopic investigation on N,N-dimethylbenzylamine based cyclopalladated compounds containing isonicotinamide

  摘要：

  本研究描述了[Pd(dmba)(Cl)(iso)]（1）、[Pd(dmba)(NCO)(iso)]（2）、[Pd(dmba)(N3)(iso)]（3）和[Pd(dmba)(Br)(iso)]（4）（dmba ；= N,N′-二甲基苄胺；iso = 异烟酰胺）化合物。通过红外光谱（IR）、差热分析（DTA）和热重分析（TG）对复合物进行了研究，并通过 X 射线粉末衍射鉴定了热分解残留物为 Pdo。配合物的热稳定性顺序为 [Pd(dmba)(Cl)(iso)] (1) > [Pd(dmba)(Br)(iso)] (4) > [Pd(dmba)(NCO)(iso)] (2) > [Pd(dmba)(N3)(iso)] (3)。

  DOI：

  10.1007/s10973-009-0251-9
• 作为产物：
  描述：

  [Pd(N,N'-dimethylbenzylamine)(μ-NCO)]2 、 4-吡啶甲酰胺 以 甲醇 、 丙酮 为溶剂， 生成 [Pd(N,N'-dimethylbenzylamine)(NCO)(isonicotinamide)]
  参考文献：
  名称：

  Thermal and spectroscopic investigation on N,N-dimethylbenzylamine based cyclopalladated compounds containing isonicotinamide

  摘要：

  本研究描述了[Pd(dmba)(Cl)(iso)]（1）、[Pd(dmba)(NCO)(iso)]（2）、[Pd(dmba)(N3)(iso)]（3）和[Pd(dmba)(Br)(iso)]（4）（dmba ；= N,N′-二甲基苄胺；iso = 异烟酰胺）化合物。通过红外光谱（IR）、差热分析（DTA）和热重分析（TG）对复合物进行了研究，并通过 X 射线粉末衍射鉴定了热分解残留物为 Pdo。配合物的热稳定性顺序为 [Pd(dmba)(Cl)(iso)] (1) > [Pd(dmba)(Br)(iso)] (4) > [Pd(dmba)(NCO)(iso)] (2) > [Pd(dmba)(N3)(iso)] (3)。

  DOI：

  10.1007/s10973-009-0251-9

文献信息

• Antiprotozoal Activity of the Cyclopalladated Complexes Against<i>Leishmania amazonensis</i>and<i>Trypanosoma cruzi</i>
  作者：Angela M. A. Velásquez、Rodrigo A. de Souza、Thaís G. Passalacqua、Aline R. Ribeiro、Mateus Scontri、Chung M. Chin、Leticia de Almeida、Mayara L. Del Cistia、João A. da Rosa、Antonio E. Mauro、Marcia A. S. Graminha

  DOI：10.5935/0103-5053.20150360

  日期：——

  The present study describes the antiprotozoal activities of four cyclopalladated compounds, [Pd(dmba)(mu-Cl)](2), [Pd(dmba)(NCO)(isn)], [Pd(dmba)(N-3)(isn)] and [Pd(dmba)(mu-NCO)](2), (dmba: N,N'-dimethylbenzylamine and isn: isonicotinamide), against the diseases leishmaniasis (Leishmania amazonensis and Leishmania infantum), Chagas disease (Trypanosoma cruzi) and human African trypanosomiasis (Trypanosoma brucei). [Pd(dmba)(mu-NCO)](2) exhibited good leishmanicidal and trypanocidal activities against L. amazonensis and T. cruzi intracellular amastigote forms, with a 50% inhibitory concentration (IC50) value of less than 9 mu M and selectivity indexes of 14.47 and 28.42, respectively. Stability essays were conducted in phosphate buffer saline (PBS) pH 7.0 and showed that [Pd(dmba)(mu-NCO)](2) is the most stable molecule. These findings indicate that this compound presented higher selectivity for these parasites than the other tested compounds. The data presented here suggest that this compound should be considered in the development of new and more potent drugs for the treatment of leishmaniasis and Chagas disease.